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Opiate Receptors and Antagonists Reginald Dean

Opiate Receptors and Antagonists By Reginald Dean

Opiate Receptors and Antagonists by Reginald Dean

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Summary

This volume offers a comprehensive view of recent work on opioid antagonist applications and uses in various clinical treatments. Emphasis is placed on disorders of the reward system. The book also illuminates prospects for future research.

Opiate Receptors and Antagonists Summary

Opiate Receptors and Antagonists: From Bench to Clinic by Reginald Dean

Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies.

  • Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes

  • Highlights differences and similarities between the opioid pharmacology of animals and human

  • Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence

  • Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications

Opiate Receptors and Antagonists Reviews

From the reviews:

The authors do an excellent job of providing insight into the background of the many factors related to opioid receptor antagonists. ... Overall, this work is a well written and interesting text and would be a very useful addition to the personal libraries of those medicinal chemists with a research interest in the modulation of the opioid receptor system. (Thomas E. Prisinzano, Journal of Medicinal Chemistry, Vol. 53 (2), March, 2010)

This book is focused on the therapeutic uses of opioid antagonists ranging from classical opioid antagonists to novel chemical entities. In any therapeutic field examined, the aim of book as outlined by the title-'From Bench to Clinic'-is achieved. ... The clinical applications of opioid antagonists are extensively discussed in almost all chapters of this book ... . In conclusion, this book gives an interesting analysis of the different fields of knowledge and research concerning therapeutic uses of opioid antagonists in recent years. (Agostino Marrazzo, ChemBioChem, Vol. 5, 2010)

Table of Contents

OPIOID RECEPTORS.- Ultra-Low Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance.- Upregulation of Opioid Receptors.- Imaging Human Brain Opioid Receptors: Applications to Substance Use Disorders.- Opioid Receptor Antagonists-Mediated Signaling in Immune System.- OPIOID ANTAGONISTS: CHEMISTRY AND PHARMACOLOGY.- The Chemistry and Pharmacology of Mu Opioid Antagonists.- Medicinal Chemistry of Kappa Antagonists.- The Pharmacology of Delta Opioid Antagonists.- Novel Opioid Antagonists with Mixed/Dual Selectivity.- Experimental Utility and Clinical Potential of Irreversible Opioid Antagonists.- Methylnaltrexone: A Peripherally Acting Opioid Antagonist.- SUBSTANCE ABUSE.- Opioid Antagonist Effects in Animal Models Related to Opioid Abuse: Drug Discrimination and Drug Self-Administration.- Naltrexone for Initiation and Maintenance of Opiate Abstinence.- Ultra-Low Dose Naltrexone Decreases Dependence and Addictive Properties of Opioids.- Can a Combination Formulation Containing a Neutral Opiate Antagonist Decrease the Abuse of -Agonist Opiates?.- Effects of Opioid Antagonists on the Abuse-Related Effects of Psychomotor Stimulants and Nicotine.- Potential Use of Opioid Antagonists in the Treatment of Marijuana Abuse and Dependence.- Naltrexone in Smoking Cessation: A Review of the Literature and Future Directions.- ALCOHOL AND INGESTIVE BEHAVIORS.- Opioid Antagonists and Ethanol's Ability to Reinforce Intake of Alcoholic Beverages: Preclinical Studies.- Clinical Use of Opioid Antagonists in the Treatment of Alcohol Dependence.- Preclinical Effects of Opioid Antagonists on Feeding and Appetite.- CNS Opiate Systems and Eating Disorders.- BEHAVIORAL DISORDERS.- Potential Utility of Kappa Ligands in the Treatment of Mood Disorders.- Opioid Antagonists in the Treatment of Pathological Gambling and Kleptomania.- Efficacy of Opioid Antagonists in Attenuating Self-Injurious Behavior.- Pharmacotherapeutic Effects of OpioidAntagonists in Alcohol Abusing Patients with Schizophrenia.- MEDICAL INDICATIONS.- Current Issues in the Use of Opioid Antagonists.- Emergency Room Use of Opioid Antagonists in Drug Intoxication and Overdose.- Kappa Opioid Antagonists as Pruritogenic Agents.- Clinical Effect of Opioid Antagonists on Clinical Pruritus.- Effects of Opioid Antagonists on L-Dopa-Induced Dyskinesia in Parkinson's Disease.- Endocrine Effects of Opioid Antagonists.- Opioid Antagonists in Traumatic Shock: Animal and Human Studies.- The Efficac y of Opioid Antagonists against Heatstroke-Induced Ischemia and Injury in Rats.- A Review of the Opioid System in Cancer Patients and Preliminary Results of Opioid Antagonists in the Treatment of Human Neoplasm.- DRUG DELIVERY APPROACHES.- Non-Clinical Pharmacology of VIVITROL (R): A Monthly Injectable Naltrexone for the Treatment of Alcohol Dependence.- The Development of Sustained Release Naltrexone and Clinical Use in Treating Opiate Dependency.- The Development of Proneura Technology for the Treatment of Addictions.- Development of Opioid Transdermal Delivery Systems.- Intranasal Naloxone for Treatment of Opioid Overdose.

Additional information

NLS9781617378225
9781617378225
1617378224
Opiate Receptors and Antagonists: From Bench to Clinic by Reginald Dean
Reginald Dean
Contemporary Neuroscience
New
Paperback
Humana Press Inc.
2010-11-19
757
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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Customer Reviews - Opiate Receptors and Antagonists