INTRODUCTION: AUTISM TURNS 65: A NEUROLOGIST'S BIRD'S EYE VIEW; ISABELLE RAPIN; SECTION I: HISTORICAL PERSPECTIVE, DIAGNOSIS AND CLASSIFICATION, AND EPIDEMIOLOGY; MICHAEL RUTTER; KATHERINE GOTHAM, SOMER L. BISHOP, AND CATHERINE LORD; AMI KLIN; SALLY OZONOFF, KELLY HEUNG, AND MEAGAN THOMPSON; ROY RICHARD GRINKER, MARSHALYN YEARGIN-ALLSOPP, AND COLEEN BOYLE; COMMENTARY: ISSUES IN THE CLASSIFICATION OF PERVASIVE DEVELOPMENTAL DISORDERS; PATRICK BOLTON; SECTION II: CORE FEATURES AND DEVELOPMENTAL TRAJECTORIES; PETER MUNDY; HELEN TAGER-FLUSBERG, LISA EDELSON, AND RHIANNON LUYSTER; WOUTER B. GROEN AND JAN K. BUITELAAR; JAMES W. BODFISH; REBECCA J. LANDA; TONY CHARMAN; MARSHA MAILICK SELTZER, JAN S. GREENBERG, JULIE LOUNDS TAYLOR, LEANN SMITH, GAEL I. ORSMOND, ANNA ESBENSEN, AND JINKUK HONG; COMMENTARY: ISSUES IN DEFINING THE CORE FEATURES OF AUTISM THROUGH THE LIFESPAN BY KATHERINE A. LOVELAND; SECTION III: PSYCHIATRIC AND MEDICAL CO-MORBIDITIES; ELISABETH M. DYKENS AND MIRIAM LENSE; BONNIE P. TAYLOR AND ERIC HOLLANDER; SUMA JACOB, ANGELI LANDEROS-WEISENBERGER, AND JAMES F. LECKMAN; ANGELA M. REIERSEN AND RICHARD D. TODD; J. BRUCE TOMBLIN, KARLA MCGREGOR, AND ALLISON BEAN; PETER SZATMARI AND BETH MCCONNELL; LINDSEY STERLING, ANNIE MCLAUGHLIN, AND BRYAN H. KING; MATTHEW W. MOSCONI, YUKARI TAKARAE, AND JOHN A. SWEENEY; ROBERTO TUCHMAN; PAULA GOINES, ANDREW ZIMMERMAN, PAUL ASHWOOD, AND JUDY VAN DE WATER; TIMOTHY BUIE; ANNE E. PORTER AND DANIEL G. GLAZE; COMMENTARY: AUTISM AS A MEDICAL DISORDER BY CHRISTOPHER GILLBERG; SECTION IV: BROADER AUTISM PHENOTYPE; MOLLY LOSH, RALPH ADOLPHS, AND JOSEPH PIVEN; JANET E. LAINHART AND NICHOLAS LANGE; JOHN N. CONSTANTINO; COMMENTARY: THE BROADER AUTISM PHENOTYPE: IMPLICATIONS FOR RESEARCH AND CLINICAL PRACTICE BY JEREMY R. PARR, KERSTIN WITTEMEYER, AND ANN S. LE COUTEUR; SECTION V: NEUROBIOLOGY; JOHN L. R. RUBENSTEIN; CYNTHIA M. SCHUMANN, STEVEN C. NOCTOR, AND DAVID G. AMARAL; DIANE C. CHUGANI; STEPHEN R. DAGER, NEVA M. CORRIGAN, TODD RICHARDS, AND DENNIS SHAW; MEERA E. MODI AND LARRY J. YOUNG; ERIC COURCHESNE, SARA JANE WEBB, AND CYNDI SCHUMANN; NANCY J. MINSHEW, K. SUZANNE SCHERF, MARLENE BEHRMANN, AND KATHERINE HUMPHREYS; SARA JANE WEBB, RAPHAEL BERNIER, KAREN BURNER, AND MICHAEL MURIAS; COMMENTARY: TOWARD A NEUROBIOLOGY OF AUTISM BY PAT LEVITT; SECTION VI: ETIOLOGY: GENETICS; JANINE A. LAMB; RITA M. CANTOR; JUDITH H. MILES; HANDE KAYMAKCALAN AND MATTHEW W. STATE; RICHARD PERSON, XINNA ZHANG, SOEUN KIM, MARWAN SHINAWI, AND ARTHUR L. BEAUDET; KAROLA REHNSTROM AND LEENA PELTONEN; ERIC M. MORROW AND CHRISTOPHER A. WALSH; JEFFREY L. NEUL; RANDI J. HAGERMAN, VIVIEN NARCISA, AND PAUL J. HAGERMAN; COMMENTARY: AUTISM GENETICS AND GENOMICS: A BRIEF OVERVIEW AND SYNTHESIS BY DANIEL H. GESCHWIND; SECTION VII ETIOLOGY: ENVIRONMENTAL FACTORS; IRVA HERTZ-PICCIOTTO; PATRICIA M. RODIER; MARK A. CORRALES AND MARTHA R. HERBERT; SECTION VIII: ANIMAL MODELS AND THEORETICAL PERSPECTIVES; ALICIA BLAKER, GIANLUCA DERIENZO, AND HAZEL SIVE; MU YANG, MARIA LUISA SCATTONI, KATHRYN K. CHADMAN, JILL L. SILVERMAN, AND JACQUELINE N. CRAWLEY; ELAINE HSIAO, CATHERINE BREGERE, NATALIA MALKOVA, AND PAUL H. PATTERSON; MELISSA D. BAUMAN AND DAVID G. AMARAL; RAJESH K. KANA AND MARCEL ADAM JUST; SIMON BARON-COHEN, BONNIE AUYEUNG, EMMA ASHWIN, AND REBECCA KNICKMEYER; MARCO IACOBONI; KEITH J. YODER AND MATTHEW K. BELMONTE; COMMENTARY: TRANSLATION BETWEEN DIFFERENT TYPES OF MODEL BY FRANCESCA HAPPE; SECTION IX: TREATMENT APPROACHES; TRISTRAM SMITH; LAURA SCHREIBMAN AND BROOKE INGERSOLL; STANLEY I. GREENSPAN AND SERENA WIEDER; SALLY J. ROGERS AND KATHERINE WALLACE; LYNN KERN KOEGEL, ROSY M. FREDEEN, ROBERT L. KOEGEL, AND C. ENJEY LIN; LINN WAKEFORD AND GRACE T. BARANEK; MARJORIE H. CHARLOP, ALISSA L. GREENBERG, AND GINA T. CHANG; EDWARD G. CARR; CONNIE KASARI AND JILL LOCKE; ROBIN GABRIELS; ANNETTE ESTES, VANESSA HUS, AND LAUREN ELDER; KELLY BLANKENSHIP, CRAIG A. ERICKSON, KIMBERLY A. STIGLER, DAVID J. POSEY, AND CHRISTOPHER J. MCDOUGLE; MARGARET L. BAUMAN; SUSAN L. HYMAN AND SUSAN E. LEVY; DILJA D. KRUEGER AND MARK F. BEAR; COMMENTARY: FUTURE DIRECTIONS IN THE TREATMENT OF AUTISM SPECTRUM DISORDERS BY EVDOKIA ANAGNOSTOU, MARK F. BEAR, AND GERALDINE DAWSON; SECTION X: BEST PRACTICES IN THE DIAGNOSIS AND TREATMENT OF AUTISM; ZACHARY WARREN AND WENDY L. STONE; DANIEL L. COURY; KARA HUME AND SAMUEL L. ODOM; JAMES T. MCCRACKEN; MARY CATHERINE ARANDA AND SARAH J. SPENCE; COMMENTARY: BIOETHICAL CONSIDERATIONS IN AUTISM RESEARCH AND TRANSLATION: PRESENT AND FUTURE BY HOLLY K. TABOR; SECTION XI: PUBLIC POLICY; DJESIKA AMENDAH, SCOTT D. GROSSE, GEORGINA PEACOCK, AND DAVID S. MANDELL; THOMAS INSEL AND SUSAN A. DANIELS; PETER H. BELL AND CRAIG SNYDER; TEMPLE GRANDIN