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Thalassemia, An Issue of Hematology/Oncology Clinics of North America Summary

Thalassemia, An Issue of Hematology/Oncology Clinics of North America: Volume 37-2 by Edward J. Benz,Jr, MD (Professor, Pediatrics, Richard and Susan Smith Professor, Medicine, Professor, Genetics,Harvard Medical School ,President and CEO, Emeritus, Office of the President, Dana-Farber Cancer Institute)

In this issue of Hematology/Oncology Clinics, guest editors Drs. Edward J. Benz, Jr. and Vijay G. Sankaran bring their considerable expertise to the topic of Thalassemia. Top experts in the field provide an overview of the history, epidemiology, pathogenic mechanisms, and clinical management of the thalassemia syndromes. Contains 16 practice-oriented topics including molecular basis and genetic modifiers of thalassemia; fetal hemoglobin in thalassemia; clinical complications and their management; iron chelation in thalassemia; fertility and pregnancy in women with transfusion-dependent thalassemia; gene therapy and genome editing in thalassemia; emerging medical therapies for thalassemia; and more. Provides in-depth clinical reviews on thalassemia, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Table of Contents

Introduction to the Thalassemia Syndromes: Molecular Medicine's Index Case The Need for Translational Epidemiology in Beta Thalassemia Syndromes:A Thalassemia International Federation Perspective Molecular Basis and Genetic Modifiers of Thalassemia Fetal Hemoglobin Regulation in Beta-Thalassemia Clinical Classification, Screening, and Diagnosis in Beta-Thalassemia and Hemoglobin E/Beta-Thalassemia The Clinical Phenotypes of Alpha Thalassemia Pathogenic Mechanisms in Thalassemia I: Ineffective Erythropoiesis and Hypercoagulability Pathogenic Mechanisms in Thalassemia II: Iron Overload Clinical Complications and Their Management Clinical Challenges with Iron Chelation in Beta Thalassemia Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia Hematopoietic Stem Cell Transplantation in Thalassemia Gene Therapy and Gene Editing for b-Thalassemia Emerging Therapies in b-Thalassemia

Additional information

NGR9780443183201
9780443183201
0443183201
Thalassemia, An Issue of Hematology/Oncology Clinics of North America: Volume 37-2 by Edward J. Benz,Jr, MD (Professor, Pediatrics, Richard and Susan Smith Professor, Medicine, Professor, Genetics,Harvard Medical School ,President and CEO, Emeritus, Office of the President, Dana-Farber Cancer Institute)
New
Hardback
Elsevier Health Sciences
2023-03-20
240
N/A
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