Leonardo and Einstein...Beethoven and Michelangelo...Thomas Edison and Steve Jobs: they are among the great minds who dazzled us with their brilliance, astounded us with their creative gifts and seemed to carry the human race into the future through sheer force of will. Yet even as we admire the outsized nature of their contributions to civilization, such exceptionally gifted people provoke us to ask: What are the wellsprings of genius? How is it acquired? What are its hallmarks, its drawbacks, its surprising side-effects? Now TIME profiles history's most gifted and inventive humans and explores the work of scientists who are using advanced technologies in their attempts to isolate and quantify the nature of genius itself. We'll explore the tantalizing questions surrounding human brilliance: Is genius the product of nature-or nurture? Is there a genetics of genius? Can science find new ways to enhance our intellectual and creative powers? How are child prodigies shaped? Is there a link between genius and mental instability? And can the experience of those with brain injuries open new windows into the nature of genius?