The world's population has been decimated by the Change, a chain reaction of events triggered by global warming. In Europe, governments have fallen, cities have crumbled and the wheels of production have ground to a halt. The Alps region, containing most of the continent's remaining fresh water, has become a closed state with heavily fortified borders. Survivors cling on by trading through the Runners, truck drivers who deliver cargo and take a percentage. Amid the ruins of central Germany, two Runners, Cassady and Ghazi, are called on to deliver medical supplies to a research base deep in the Italian desert, where scientists claim to be building a machine that could reverse the effects of the Change. Joining the pair are a ragtag collection of drivers, all of whom have something to prove. Standing in their way are starving nomads, crumbling cities, hostile weather and a rogue state hell-bent on the convoy's destruction. And there's another problem: Cassady is close to losing his nerve.