These meditations present the mystery of Pentecost, from Luke in Acts, John in his Gospel, and Paul in his Letters. By placing these diverse but complementary points of view together, Cantalamessa provides priests, students, and interested lay people with a three-dimensional image of the coming of the Spirit, particularly suited to promote catechesis and devotion. Fr. Cantalamessa originally presented these meditations in his capacity as preacher to the papal household.

Chapters are And They Began to Speak in Different Tongues: The Lukan Pentecost and the Spirit of Unity, You Will Receive Power When the Holy Spirit Comes Upon You: The Lukan Pentecost and the Spirit of Prophecy, He Breathed on Them and Said, 'Receive the Holy Spirit': The Johannine Pentecost and the Spirit of Truth, But One and the Same Spirit Produces all of These: The Pauline Pentecost and the 'Person' of the Holy Spirit.