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Contributors vii Preface xiii SECTION I: BASIC PRINCIPLES AND CONSIDERATIONS OF RATIONAL CHEMOTHERAPY AND MOLECULAR TARGETED THERAPY 1 1 Biologic and Pharmacologic Basis of Cancer Chemotherapy 1 Roland T. Skeel 2 Biologic Basis of Molecular Targeted Therapy 16 Osama E. Rahma and Samir N. Khleif 3 Systematic Assessment of the Patient With Cancer and Consequences of Treatment 45 Roland T. Skeel 4 Selection of Treatment for the Patient With Cancer 63 Roland T. Skeel SECTION II: CHEMOTHERAPY AND MOLECULAR TARGETED THERAPY OF HUMAN CANCER 69 5 Carcinomas of the Head and Neck 69 Barbara A. Murphy 6 Carcinoma of the Lung 94 David E. Gerber and Joan H. Schiller 7 Carcinomas of the Gastrointestinal Tract 120 Maxwell Vergo and Al B. Benson III 8 Carcinomas of the Pancreas, Liver, Gallbladder, and Bile Ducts 151 Timothy J. Kennedy and Steven K. Libutti 9 Carcinoma of the Breast 172 Patrick Glyn Morris and Clifford A. Hudis 10 Gynecologic Cancer 199 Thomas McNally, Richard T. Penson, Chau Tran, and Michael J. Birrer 11 Urologic and Male Genital Cancers 233 Brendan D. Curti and Craig R. Nichols 12 Kidney Cancer 250 Mark T. Andolina, Colleen Darnell, and Olivier Rixe 13 Thyroid and Adrenal Carcinomas 258 Haitham S. Abu-Lebdeh, Michael E. Menefee, and Keith C. Bible 14 Melanomas and Other Cutaneous Malignancies 277 Ragini Kudchadkar and Jeffrey S. Weber 15 Primary and Metastatic Brain Tumors 297 April Fitzsimmons Eichler and Tracy T. Batchelor 16 Soft-Tissue Sarcomas 310 Robert S. Benjamin 17 Bone Sarcomas 324 Robert S. Benjamin 18 Acute Leukemias 337 Olga Frankfurt and Martin S. Tallman 19 Chronic Leukemias 394 Khaled el-Shami and Bruce D. Cheson 20 Myeloproliferative Neoplasms and Myelodysplastic Syndromes 418 Elias Jabbour and Hagop Kantarjian 21 Hodgkin Lymphoma 437 Richard S. Stein and David S. Morgan 22 Non-Hodgkin Lymphoma 451 Mark Roschewski and Wyndham H. Wilson 23 Multiple Myeloma, Other Plasma Cell Disorders, and Primary Amyloidosis 491 Rachid Baz and Mohamad A. Hussein 24 Metastatic Cancer of Unknown Origin 514 James M. Leonardo 25 HIV-Associated Malignancies 523 Thomas S. Uldrick, Mark N. Polizzotto, and Robert Yarchoan SECTION III: SUPPORTIVE CARE OF PATIENTS WITH CANCER 543 26 Side Effects of Chemotherapy and Molecular Targeted Therapy 543 Janelle M. Tipton 27 Infections: Etiology, Treatment, and Prevention 566 Thomas J. Walsh and Joan M. Duggan 28 Transfusion Therapy, Bleeding, and Clotting 596 Mary R. Smith and NurJehan Quraishy 29 Oncology Emergencies and Critical Care Issues: Spinal Cord Compression, Cerebral Edema, Superior Vena Cava Syndrome, Anaphylaxis, Respiratory Failure, Tumor Lysis Syndrome, Hypercalcemia, and Bone Metastasis 617 Roland T. Skeel 30 Malignant Pleural, Peritoneal, and Pericardial Effusions and Meningeal Infi ltrates 636 Rekha T. Chaudhary 31 Cancer Pain 649 Richard T. Lee and Michael J. Fisch 32 Emotional and Psychiatric Problems in Patients with Cancer 678 Kristi Skeel Williams and Kathleen S.N. Franco-Bronson SECTION IV: CHEMOTHERAPEUTIC AND MOLECULAR TARGETED AGENTS AND THEIR USE 693 33 Classification, Use, and Toxicity of Clinically Useful Chemotherapy and Molecular Targeted Therapy 693 Roland T. Skeel Appendix A: Surface Area of Adults from Height and Mass 843 Nomogram for Determining BodyAppendix B: Surface Area of Children from Height and Mass 844 Nomogram for Determining BodyIndex 845