Having delivered the body of wanted outlaw Mason Holt to the sheriff at Diablo Creek, infamous bounty hunter Iron Eyes collapses, badly wounded, and his would-be sweetheart Squirrel Sally desperately tries to find a doctor to help him. However, unknown to Sally, she is heading into a dangerous and uncharted desert where a mysterious tribe of Indians live. Then when Holt's older brothers discover their sibling is dead, they vow revenge and set out after the man who killed him. Soon both outlaws and Indians alike realize how dangerous Iron Eyes is.