Now in its Third Edition, Step-Up is the most comprehensive systems-based review for the USMLE Step 1. The book has been widely acclaimed for its systems-based organization, which parallels the USMLE Step 1 content outline and helps students synthesize the information from their basic science courses. The popular, user-friendly format features numerous charts and diagrams and Quick Hits notes in the margins that help students integrate concepts across systems. For this edition, the author has added numerous clinical vignettes and new mnemonics to each chapter. Pharmacology has been further integrated into the systems-based format with new illustrations, tables, and references.