A year after getting shot on a job that took a dangerous turn, Jane Whitefield has settled into the quiet life of a suburban housewife - or so she thinks. One morning, returning from a long run, she's met by an unusual sight: the female leaders of the eight Seneca clans waiting in her driveway. Jane's childhood friend from the reservation is wanted by the police for murder, and the clan mothers believe she is the only one who can find him.

So Jane sets out to retrace a journey she took with Jimmy when they were fourteen years old, and soon discovers that the police aren't the only ones after her childhood friend. As the chase intensifies, the number of people caught up in the deadly plot grows, and Jane is the only one who can protect those in danger...