Illustrating concepts and types of toxicity from a mechanistic point of view, this book focuses on research procedures in toxicology. The book uses examples of chemical intoxicants to illustrate mechanisms in each stage of toxicity.
Scope of Toxicology
Stages in the Induction of Toxicity
Kinetics and End-points
Acute and Chronic Intoxication
Delivery of Intoxicant: Decrease in Delivery to the Target
Delivery of Intoxicant: Bioactivation and Increase in Delivery to the Target
Initiating Reactions with Targets
Biological Consequences of Initiating Reactions with Targets
Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds
Selective Toxicity, Animal Experimentation and In Vitro Methods
Biomonitoring
Epidemiology
Environmental and Ecotoxicology
Reflections, Research and Risk