This resource gives professionals the foundation of clinical knowledge they will need to work with high-risk newborns. It includes research findings and practical guidelines clinicians will use to promote the well-being of infants in the NICU and to involve and support their families. It includes a synopsis of the functional abilities of premature infants, detailed guidelines of positioning and feeding, an overview of medical conditions of newborns and commonly used interventions, and information on following up with high-risk infants.