Part 1 Consciousness, major syndromes and approach: consciousness - definition and context; major syndromes of impaired consciousness; clinical assessment, investigation and initial management. Part 2 Physical insults and structural lesions causing coma: herniations; intracranial hemorrhage; trauma; neoplasia; hypothermia and hyperthermia; electrical injuries; burn encephalopathy. Part 3 Impaired consciousness and inflammatory conditions: CNS infections; other inflammatory diseases affecting CNS - sepsis-associated encephalopathy, collagen-vascular diseases, acute disseminated encephalomyelitis, "toxic encephalopathy" and Reye's syndrome. Part 4 Metabolic, nutritional, ischaemic and toxic encephalopathies: metabolic encephalopathies, mineral and electrolyte disturbances, endocrinopathies, organ failure; nutritional disorders; ischaemia and anoxia - focal and generalized; drugs - poisoning, pharmacologic considerations in impaired consciousness. Part 5 Episodic impairment of consciousness: seizures; other causes of episodic loss of consciousness - syncope, transient vascular events, concussion, metabolic and toxic causes, sleep-related disorders, idiopathic recurring stupor, transient globale amnesia, transiently raised intracranial pressure, psychiatric disorders, uncertain aetiologies. Part 6 Impaired consciousness in clinical contexts: the emergency room; medical and surgical ICUs; the transplant ward; the maternity ward; neuro-degenerative disorders; ethics.
