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Transcription Factors and Human Disease Gregg L. Semenza (Associate Professor of Pediatrics, Center for Medical Genetics, Associate Professor of Pediatrics, Center for Medical Genetics, Johns Hopkins University School of Medicine, USA)

Transcription Factors and Human Disease von Gregg L. Semenza (Associate Professor of Pediatrics, Center for Medical Genetics, Associate Professor of Pediatrics, Center for Medical Genetics, Johns Hopkins University School of Medicine, USA)

Transcription Factors and Human Disease Gregg L. Semenza (Associate Professor of Pediatrics, Center for Medical Genetics, Associate Professor of Pediatrics, Center for Medical Genetics, Johns Hopkins University School of Medicine, USA)

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Zusammenfassung

This work discusses the basic science of transcriptional regulation, and describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites.

Transcription Factors and Human Disease Zusammenfassung

Transcription Factors and Human Disease Gregg L. Semenza (Associate Professor of Pediatrics, Center for Medical Genetics, Associate Professor of Pediatrics, Center for Medical Genetics, Johns Hopkins University School of Medicine, USA)

Transcription factors are essential mediators of the genetic programs that control development and physiology. This exciting book presents current knowledge of transcription factors from two viewpoints. First, the basic science of transcriptional regulation is discussed. Second, inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites are described. Readers are also introduced to the involvement of transcription factors in somatic cell genetic disease (cancer) and epigenetic disease (teratogenesis).

Transcription Factors and Human Disease Bewertungen

This book has many strengths. It is very weel written in a clear, persuasive style. The enthusiam and depth of knowledge that Gregg Semenza has for his subject is evident in every chapter.... The referencing is also very well judged, being both selective and comprehensive. --Human Genetics ...this book will be very useful to two diverse audiences. Clinicians will be stimulated by the many examples and suggestions provided, and hopefully will look at their patients who have congenital and hereditary defects from a different perspctive. Molecular biologists will be intrigued by the transcriptional phenomena hidden behind a particular phenotype. This book represents an important example of how medical sciences and molecular biology may interact profitably.--Nature Medicine The most useful chapters of the book are those...organized by transcription factor family....Students of human biology will find this material accessible, useful, and remarkably thorough....--CELL

Inhaltsverzeichnis

Part I: Transcriptional Regulation ; 1. Gene Expression and Transcriptional Regulation ; 2. Cis-acting Transcriptional Regulatory Elements ; 3. Trans-acting Factors ; Part II: Transcriptional Pathophysiology ; 4. Mutations in Cis-acting Transcriptional Regulatory Elements ; 5. Mutations in Genes Encoding Transcription Factors: The Nuclear Receptor Superfamily ; 6. Other Zinc-Finger Proteins: WT1 and GL13 ; 7. PAX Proteins ; 8. bHLH Proteins ; 9. Homeodomain Proteins ; 10. HMG Domain Proteins ; 11. POU Domain Proteins ; 12. Other Transcriptional Factor Families ; 13. Co-activators ; 14. General Transcription Factors ; 15. Somatic Cell Genetic Disease: Cancer ; 16. Epidenetic Disease: Teratogenesis

Zusätzliche Informationen

GOR013951570
9780195112399
0195112393
Transcription Factors and Human Disease Gregg L. Semenza (Associate Professor of Pediatrics, Center for Medical Genetics, Associate Professor of Pediatrics, Center for Medical Genetics, Johns Hopkins University School of Medicine, USA)
Gregg L. Semenza (Associate Professor of Pediatrics, Center for Medical Genetics, Associate Professor of Pediatrics, Center for Medical Genetics, Johns Hopkins University School of Medicine, USA)
Oxford Monographs on Medical Genetics
Gebraucht - Sehr Gut
Gebundene Ausgabe
Oxford University Press Inc
1998-10-29
382
N/A
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