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Protein Condensation James D. Gunton (Lehigh University, Pennsylvania)

Protein Condensation von James D. Gunton (Lehigh University, Pennsylvania)

Protein Condensation James D. Gunton (Lehigh University, Pennsylvania)


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Zusammenfassung

For an interdisciplinary graduate and academic audience, this book describes protein crystallization from solution. The first part explains the production of high quality protein crystals, which is necessary to understand protein structure and function. The second part concerns the aggregation of proteins in undesirable ways, which can cause disease.

Protein Condensation Zusammenfassung

Protein Condensation: Kinetic Pathways to Crystallization and Disease James D. Gunton (Lehigh University, Pennsylvania)

The quest to understand the condensation of proteins from solutions is a rapidly evolving field. The purpose of this book is to bring to an interdisciplinary audience the state-of-the-art in current research. The first part of the book deals with issues related to the production of high quality protein crystals from solution. Since protein function is determined by structure, high quality protein crystals must be grown in order to determine their structure by X-ray crystallography. The book also discusses diseases that occur due to undesired protein condensation, an increasingly important subject. Examples include sickle cell anemia, cataracts and Alzheimer's disease. Current experimental and theoretical work on these diseases is discussed, which seeks understanding at a fundamental, molecular level, to prevent the undesired condensation from occurring. The book, containing color plate sections, is suitable for graduate students and academic researchers in physics, chemistry, structural biology, protein crystallography and medicine.

Protein Condensation Bewertungen

'... the text covers just about anything a researcher would need to know of the many research areas of protein crystallisation. From statistical tests to theoretical models and mathematics, Gunton et al. appear to include the lot.' Journal of Biological Education

Über James D. Gunton (Lehigh University, Pennsylvania)

J. D. Gunton is Joseph A. Waldschmitt Professor of Physics at Lehigh University in Pennsylvania. He is the author of approximately 200 articles in refereed journals on equilibrium and nonequilibrium phase transitions. He is a Rhodes Scholar and a Danforth Fellow, and a Fellow of the American Physical Society. A. Shiryayev is a doctoral candidate at Lehigh University. He has already published several refereed articles that deal with the condensation of globular proteins. D. L. Pagan received is PhD degree from Lehigh University in 2005. He has authored several refereed articles on the condensation of globular proteins.

Inhaltsverzeichnis

Preface; 1. Introduction; 2. Globular protein structure; 3. Experimental methods; 4. Thermodynamics and statistical mechanics; 5. Protein-protein interactions; 6. Theoretical studies of equilibrium; 7. Nucleation theory; 8. Experimental studies of nucleation; 9. Lysozyme; 10. Some other globular proteins; 11. Membrane proteins; 12. Crystallins and cataracts; 13. Sickle hemoglobin and sickle cell anemia; 14, Alzheimer's disease; Index.

Zusätzliche Informationen

GOR007242054
9780521851213
0521851211
Protein Condensation: Kinetic Pathways to Crystallization and Disease James D. Gunton (Lehigh University, Pennsylvania)
Gebraucht - Sehr Gut
Gebundene Ausgabe
Cambridge University Press
20070920
376
N/A
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