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DNA Microarrays and Gene Expression Pierre Baldi (University of California, Irvine)

DNA Microarrays and Gene Expression von Pierre Baldi (University of California, Irvine)

DNA Microarrays and Gene Expression Pierre Baldi (University of California, Irvine)

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Zusammenfassung

DNA microarrays are in the process of revolutionizing biology and medicine. They can provide a snapshot of the level of gene expression in a cell and are therefore a powerful tool with which to study biological phenomena at the molecular level. This 2002 book explores this powerful technology.

DNA Microarrays and Gene Expression Zusammenfassung

DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling Pierre Baldi (University of California, Irvine)

Massive data acquisition technologies, such as genome sequencing, high-throughput drug screening, and DNA arrays are in the process of revolutionizing biology and medicine. Using the mRNA of a given cell, at a given time, under a given set of conditions, DNA microarrays can provide a snapshot of the level of expression of all the genes in the cell. Such snapshots can be used to study fundamental biological phenomena such as development or evolution, to determine the function of new genes, to infer the role individual genes or groups of genes may play in diseases, and to monitor the effect of drugs and other compounds on gene expression. Originally published in 2002, this inter-disciplinary introduction to DNA arrays will be of value to anyone with an a interest in this powerful technology.

DNA Microarrays and Gene Expression Bewertungen

Review of the hardback: 'The book, written by Baldi and Hatfield, is an important and timely addition to the DNA microarray literature ... the first several chapters of the book provide an easy-to-digest overview of the current state of DNA microarrays.' Briefings in Functional Genomics & Proteomics
Review of the hardback: 'Writing a book such as this was a challenging remit and one that the authors have achieved with great success.' Human Genomics
Review of the hardback: 'I recommend very highly this book to statisticians in particular.' Journal of Statistical Computation & Simulation

Über Pierre Baldi (University of California, Irvine)

Pierre Baldi is Professor and Director of the Institute for Genomics and Bioinformatics in the Department of Information and Computer Science and in the Department of Biological Chemistry in the College of Medicine at the University of California, Irvine. Wes Hatfield is a Professor in the Department of Microbiology and Molecular Genetics in the College of Medicine and the Department of Chemical Engineering and Material Sciences in the School of Engineering at the University of California, Irvine.

Inhaltsverzeichnis

Preface; 1. A brief history of genomics; 2. DNA array formats; 3. DNA array readout methods; 4. Gene expression profiling experiments: problems, pitfalls and solutions; 5. Statistical analysis of array data: inferring changes; 6. Statistical analysis of array data: dimensionality reduction, clustering, and regulatory regions; 7. Survey of current DNA array applications; 8. Systems biology: overview of regulatory, metabolic and signaling networks.

Zusätzliche Informationen

GOR005637906
9780521800228
0521800226
DNA Microarrays and Gene Expression: From Experiments to Data Analysis and Modeling Pierre Baldi (University of California, Irvine)
Pierre Baldi (University of California, Irvine)
Gebraucht - Sehr Gut
Gebundene Ausgabe
Cambridge University Press
20020919
230
N/A
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