Now in its second edition, this updated work examines the implications of co-existing disease for the management of anaesthesia. The text is organized by disease rather than anaesthetic procedure. Taking an analytic approach to each disease, chapters provide information on definition, current pathophysiology, significant pre-operative, intra-operative and post-operative factors of the disease processes and anaesthetic judgement and management. Many chapters have been rewritten to include updated knowledge about diseases of the heart, nervous system, gastrointestinal system, metabolism, kidneys, liver and biliary tract. New discoveries about infectious diseases and nutritional disorders are also included. This book is designed to be of interest to anaesthetists, respiratory therapists and doctors and nurses working in intensive and critical care medicine.