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Adaptive responses; cell death; dysplasia and neoplasia; tissue responses; genetic, environmental and immune factors in disease; cardiovascular system; respiratory system; alimentary system; liver, pancreas and biliary systems; lymphoid and haemopoietic systems; endocrine system; urinary system; male reproductive system; female reproductive system; central and peripheral nervous system; the eye and the ear; skin and breast; muscle, bone, joint and soft tissues; important multisystem disorders.