Part I: Novel Approaches for the Treatment of Epilepsy
1. Inflammatory Cytokines as Targets for Epilepsy Drug Therapy
Maria-Leonor Lopez-Meraz, Jesus-Servando Medel-Matus, and Jerome Niquet
2. The Use of Anti-Inflammatory Drugs in Epilepsy
Maria Guadalupe Valle-Dorado, Laura Elena Cordova-Davalos, Daniel Perez-Perez, Rosalinda Guevara-Guzman, and Luisa Rocha
3. Carbonic Anhydrase and Epilepsy
Luciana Gavernet
4. Synaptic Vesicle Protein 2A as a Novel Pharmacological Target with Broad Potential for New Antiepileptic Drugs
Luz Adriana Pichardo-Macias, Itzel Jatziri Contreras-Garcia, Sergio R. Zamudio, Edgar Mixcoha, and Julieta G. Mendoza-Torreblanca
5. Do Cannabinoids Represent a Good Therapeutic Strategy for Epilepsy?
Cecilia Zavala-Tecuapetla and Luisa Rocha
6. Glutamate Receptors as Targets for Novel Antiepileptic Drug Therapy
Manola Cuellar-Herrera, Cesar E. Santana-Gomez, Francia Carmona-Cruz, Daruni Vazquez-Barron, Francisco Velasco, and Ana L. Velasco
7. Neurosteroid Regulation of Seizures: Role of GABAA Receptor Plasticity
Suchitra Joshi and Jaideep Kapur
8. Erythropoietin as Potential Neuroprotective and Antiepileptogenic Agent in Epilepsy and Refractory Epilepsy
Amalia Marelli, Liliana Czornyj, Luisa Rocha, and Alberto Lazarowski
9. Caloric Restriction and Dietary Treatments of Epilepsy: Mechanistic Insights for Drug Discovery
Karla G. Carvajal Aguilera and Bryan V. Phillips Farfan
10. Gene Therapy in Epilepsy
Miguel A. Lopez-Garcia, Iris A. Feria-Romero, Julia J. Segura-Uribe, David Escalante-Santiago, and Sandra Orozco-Suarez
Part II: Innovative Solutions for the Screening of New Antiepileptics Drugs and Addressing the Multi-Drug Resistance Issue Epilepsy
11. Human Brain Tissue as a Model for the Study of Epilepsy
Leonardo Lara-Valderrabano, Ivette Banuelos-Cabrera, Victor Navarrete-Modesto, and Luisa Rocha
12. The Blood-Brain Barrier and the Design of New Antiepileptic Drugs
Gabriela Rogel-Salazar and Hiram Luna-Munguia
13. Virtual Screening Applications in the Search of Novel Antiepileptic Drug Candidates
Alan Talevi and Luis E. Bruno-Blanch
14. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Ligand-Based Approximations
Manuel Couyoupetrou, Mauricio Di Ianni, Melisa Gantner, Guido Pesce, Roxana Peroni, Alan Talevi, and Luis E. Bruno-Blanch
15. Discovering New Antiepileptic Drugs Addressing the Transporter Hypothesis of Refractory Epilepsy: Structure-Based Approximations
Pablo Palestro and Luciana Gavernet
16. Nanoformulations of Antiepileptic Drugs: In Vitro and In Vivo Studies
Maria E. Ruiz and Guillermo R. Castro
Part III: Potential Contributions of Network Pharmacology and Drug Repurposing in Antiepileptic Drug Discovery
17. Side Effects of Antiepileptic Drugs
Hana Kubova
18. Network Pharmacology and Epilepsy
Alan Talevi
19. The Importance of Drug Repurposing in the Field of Antiepileptic Drug Development
Alan Talevi