In this issue of Heart Failure Clinics, guest editors Drs. Alberto M. Marra, Pietro Ameri, and Alexander E. Sherman bring their considerable expertise to Challenges in Pulmonary Hypertension. Top experts in the field cover key topics such as gender aspects in pulmonary hypertension; PAH in connective tissue diseases beyond systemic sclerosis; genetic background of high altitude pulmonary edema; oxygen therapy in pulmonary vascular disease; and more. Contains 13 relevant, practice-oriented topics including rare forms of pulmonary hypertension; management of SARS-CoV-2 infection and COVID-19 in patients with pulmonary arterial hypertension; anabolic deficiency in pulmonary arterial hypertension; anticoagulation in pulmonary hypertension; and more. Provides in-depth clinical reviews on challenges in pulmonary hypertension, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.