Introduction: Challenges of Implementing Research Demonstration Programs by Bennett W. Fletcher, James A. Inciardi, and Arthur M. Horton Methadone Programs Implementing an Enhanced Methadone Maintenance Program for HIV Risk Reduction in Los Angeles by Christine Grella and M. Douglas Anglin Innovations to Improve Retention on Methadone by James F. Maddux, Kenneth N. Vogtsberger, David P. Desmond, and Moses Esquivel Implementing Mobile Drug Abuse Treatment: Problems, Procedures, and Perspectives by Karst J. Besteman and Joseph V. Brady Residential Programs Walking the Walk, Talking the Talk: Implementation and Process Analysis Issues in Four Residential Treatment Models by Benjamin F. Lewis, Frances Garfield, Karen C. Orsini, and Jane McCusker When Worlds Collide: Establishing CREST Outreach Center by James A. Inciardi and Dorothy Lockwood Bringing Experimental Research Designs into Existing Treatment Programs: The Case of Community-Based Treatment of the Dually Diagnosed by Michael Rahav, James J. Rivera, John Collins, Daisy Ng-Mak, Elizabeth L. Sturz, Elmer L. Struening, Bert Pepper, Bruce G. Link, and Benjamin Gross Case Management Programs Case Management with Intravenous Drug Users: Implementation Issues and Strategies by Cheryl L. Mejta, Peter J. Bokos, Judith H. Mickenberg, and E. Michael Maslar Assertive Community Treatment: Obstacles to Implementation by Frank R. Scarpitti, James A. Inciardi, and Steven S. Martin Implementing Innovations in Drug Treatment: Case Management and Treatment Induction in the Enhanced Treatment Project by Harvey A. Siegal, Richard C. Rapp, James Fisher, Phyllis Cole, and Joseph H. Wagner Multimodality and Other Eclectic Programs Modified Therapeutic Community Methods in Methadone Maintenance (Passages): Problems and Issues by George De Leon, Graham L. Staines, Stanley Sacks, Robert Hilton, and Ronald Brady Starting Up Treatment Demonstration Projects: Organizational Lessons from a School of Hard Knocks by Victor Lidz, Richard J. Lamb, Martin Y. Iguchi, and Jerome J. Platt Delivering and Evaluating Outpatient Treatment: Finding a Practical Balance by Lois R. Chatham and D. Dwayne Simpson Challenges in Developing a Drug Abuse Day Treatment Program by Joseph Guydish, David Werdegar, Monica Chan, Ethan Nebelkopf, and Alfonso Acampora The Comprehensive Vocational Enhancement Program: A Case Study in Successful Implementation by Robert B. Millman, Irving Finkelstein, Holly Robinson, Paul Engelhart, Paula H. Kleinman, Martin Lesser, and Ching Hsu Providing Free Drug Abuse Treatment to Reduce the Spread of AIDS in St. Louis: Barriers to Care by Rumi K. Price, Linda B. Cottler, Wilson M. Compton III, Audrey M. Shillington, Daniel Claverie, Greg Asmus, William Dotson, Oval Miller, and Malaika Horne Index