Significant advances continue to be made in elucidating the cellular and molecular mechanisms of cardiovascular diseases. Recent technological innovations - in molecular therapies and local drug delivery - now permit clinicians to exploit information on pathophysiology in order to treat these conditions more effectively. In this work, the authors bring together a team of authorities in the field, integrate basic and clinical research data with state-of-the-art engineering and technology, to give the cardiovascular physician a review of this area. Taking a problem-solving approach, the authors explain the applications and limitations of the new therapies, practical considerations and prospects for the future.