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Perinatal and Developmental Epigenetics Summary

Perinatal and Developmental Epigenetics: Volume 35 by Garima Singh (Department of Botany, Pachhunga University College (PUC) campus, Mizoram University, Aizawl, Mizoram, India)

Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood.

About Garima Singh (Department of Botany, Pachhunga University College (PUC) campus, Mizoram University, Aizawl, Mizoram, India)

Dr. Singh is working as Assistant Professor at Pachhunga University College (PUC) campus of Mizoram Central University, Mizoram, India. She has completed her doctorate in 2018 from Mizoram University, India in plant sciences and worked on the pharmaceutical potential of selected traditional medicinal plants. Dr. Singh has 8 years of research experience and has published several research papers in national and international journals having high impact factor like Scientific reports, BMC complementary and alternative medicine, frontiers in plant sciences, etc. Dr. Singh has awarded for her work by several agencies while presenting her research work in India and abroad. Her expertise lies in the areas of utilization of traditional medicinal plants for sustainable development, secondary metabolites extraction and documentation of traditional medicinal pants. Dr. Singh is running one externally funded project to explore the pharmaceutical potential of some selected traditional medicinal plants located in North East India.

Table of Contents

Section I: The ever-growing complexity of epigenetic regulation of gene expression 1. Epigenetic regulation of gene expression: An overview of classical and recently discovered novel players: -Role of DNA methylation, Role of Histone modifications, Role of non-coding RNAs 2. Epigenetic regulation of transposable elements and their impact on developmental processes 3. Epigenetic regulation of germ cells 4. Epigenetic regulation of cis-regulatory elements and transcription factors during development 5. Genomic imprinting and developmental physiology: Intrauterine growth and postnatal period 6. Metabolic regulation of epigenetic processes 7. Role of RNA epigenetics in development Section II: Epigenetic programming of the placenta regulates short-term and long-term health outcomes 8. Epigenetic regulation of placental function 9. Role of placenta in developmental programming of sex-specific adult outcomes 10. Epigenetic changes induced by Assisted Reproductive Technologies (ART) in the placenta and its effect on developmental outcomes Section III: Epigenetics, hormones, sex and developmental programming 11. Epigenetic and hormone interaction and effect on gene regulation during prenatal and early postnatal life 12. Role of epigenetics in shaping the sex difference in immune function during development 13. Role of epigenetics in shaping sex differences in brain development and behavior 14. Role of epigenetics in shaping sex differences in heart development and later life cardiovascular disease risk Section IV: Epigenetic programming by adverse perinatal influences 15. Early life endocrine disruptors exposure and epigenetic programming 16. Early life stress exposure and epigenetic programming 17. Early life nutrition and epigenetic programming 18. Early life air pollution exposure and epigenetic programming 19. Early life substance abuse and epigenetic programming Section V: Advancing translational epigenetic research 21. Modelling early life adversity in the laboratory -: Animal models, their advantages and challenges in extrapolating findings from animal studies to humans 22. Clinical evidence of developmental programming due to early life exposures and long-term effects: Implications for public health 23. Phenotypic plasticity: Adaptive vs Maladaptive response and epigenetic changes 24. Epigenomics: A road to genome-wide characterization of epigenetic changes during development and identifying future individuals at risk of disease susceptibility Section VI: Pharmacological and non-pharmacological approaches to reprogram the developmental programming to improve the health outcomes 26. Epigenetic signatures as biomarkers of early life experiences 27. Environmental enrichment and its effect on modifying the epigenetic changes induced by early life adversity 28. Dietary targeting of epigenome and its effect on early life adverse influences 29. Early postnatal maternal care and epigenetic programming of HPA axis activity 30. Emerging field of epigenetic editing: Implication for translational purposes for diseases with developmental origin and sex bias

Additional information

NLS9780128217856
9780128217856
0128217855
Perinatal and Developmental Epigenetics: Volume 35 by Garima Singh (Department of Botany, Pachhunga University College (PUC) campus, Mizoram University, Aizawl, Mizoram, India)
New
Paperback
Elsevier Science Publishing Co Inc
2022-12-05
404
N/A
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