Part I. Physiology and Pathophysiology of Nerve Fibres: 1. Ion channels in normal and pathophysiological mammalian peripheral myelinated nerve J. M. Ritchie; 2. Molecular anatomy of the node of Ranvier: newer concepts S. G. Waxman; 3. Delayed rectifier type K+ currents in rabbit and rat axoms and Schwann cells M. Baker; 4. Axonal signals for potassium channel expression in Schwann cells T. Konishi; 5. Ion channels in human axons G. Reid; 6. An in vitro model of diabetic neuropathy: electrophysiological studies P. Grafe; 7. Autoimmunity at the neuromuscular junction J. Newsom-Davis; 8. The immunopathology and pathophysiology of experimental autoimmune encephalomyelitis M. P. Pender; 9. The pathophysiology of human demyelinating neuropathies T. E. Feasby; 10. Conduction properties of central demyelinated axons: the generation of symptoms in demyelinating disease K. J. Smith; 11. The mechanisms of relapse and remission in multiple sclerosis W. I. McDonald; 12. Glial transplantation in the treatment of myelin loss or deficiency J. Rosenbluth; Part II. Pain: 13. Human nociceptors in health and disease J. Ochoa; 14. The sensory consequences of inflammation A. Iggo; 15. Non-voluntary motor unit activity and myofascial pain syndromes R. H. Westgaard; 16. Is there a mechanism for the spinal cord to remember pain? W. D. Willis Jnr; 17. The neurophysiological basis of pain relief by acupuncture E. Shen; Part III. Control of Central Nervous System Output: 18. Synaptic transduction in neocortical neurones W. E. Crill; 19. Cortical circuits, synchronization and seizures J. G. R. Jefferys; 20. Physiologically induced changes of brain temperature and their effect on extracellular field potentials P. Anderson, E. Moser, and V. Jensen; 21. Fusimotor patterns of respiratory muscles A. Taylor, and R. Durbarba; 22. Cerebral accompaniments and functional significance of the long-latency stretch reflexes in human forearm muscles M. Aminoff, and S. Goodin; 23. The cerebellum and proprioceptive control of movement A. Prochazka et al; 24. Roles of the lateral nodulus and uvula of the cerebellum in cardiovascular control N. Nishimaru; 25. Central actions of curare and gallamine: implications for reticular reflex myoclonus W. Burke; 26. The pathophysiology of upper motoneurone disorders H-J. Freund; 27. Modulation of hypoglossal motoneurones by thyrotropin releasing hormone and serotonin A. J. Berger et al; 28. Serotonin and central respiratory disorders in the newborn G. Hilaire, D. Morin et al; 29. Are medullary respiratory neurones multipurpose neurones? L. Grelot et al; 30. Reflex control of expiratory motor output in dogs J. R. Romaniuk et al.; 31. Abnormal thoracoabdominal movements in patients with chronic lung disease M. Goldman; 32. Respiratory rhythm and apnoeas in the newborn B. Duron; 33. Cardiorespiratory interactions during apnoea C. P. Seers; 34. Impairment of respiratory control in neurological disease R. S. Howard; 35. The respiratory muscles in neurological disease G. H. Mills and M. Green; Part IV. Development, Survival, Regeneration and Death: 36. Axonal growth and plasticity in the adult nervous system J. Diamond, and A. Gloster; 37. Target dependence of motoneurones I. P. Johnson; 38. Rescue of neurones cross-regenerated into foreign targets J. B. Munson, and H. Nishimura; 39. Development and repair of neonatal mammalian spinal cord in culture J. G. Nicholls, and Z. Varga; 40. Selective neuronal vulnerability in motor neurone diseases with reference to sparing of Onuf's nucleus A. H. Pullen; 41. Excitotoxicity in motor neurone diseases C. Krieger.