This new edition maintains the objective of the previous editions of providing a relatively brief but comprehensive introduction to the initiation, development, and treatment of cancer. Current techniques in cell and molecular biology have been widely applied to the study of cancer, and the resulting new developments are introduced here. In areas such as genetic and chromosome changes, growth factors, and the biology of human leukemia, where there has been great activity, the relevant chapters have been extensively rewritten, but all the chapters have been reviewed and brought up to date.