Walking Wolf, the orphaned son of white settlers, is found as an infant by a Comanche brave and raised to be a proud warrior. He also happens to be a werewolf.

When he loses control of his darker nature, killing the woman he loves and his best friend, Walking Wolf heads out into the white man's world to learn more about who-and what-he truly is.

On his journey of self-discovery, he crosses paths with deranged killers, a traveling medicine show, a vampire gunslinger, a fellow werewolf, and historical figures Quanah Parker and Sitting Bull. But of all the dangers he faces, none are as deadly as the bounty hunter known as Witchfinder Jones.