Part 1. Fundamentals of quadruplexes and their biology Fundamentals of G-quadruplex biology F. Brad Johnson Quadruplex structure and diversity Fernaldo Richtia Winnerdy and Anh Tuan Phan Part 2. Quadruplex targets in human and other organisms Telomeric quadruplexes as therapeutic targets Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy Emanuela Ruggiero and Sara N. Richter Quadruplex detection in human cells David Monchaud Part 3. Discovery and design of quadruplex-binding compounds An overview of quadruplex ligands: Their common features and chemotype diversity Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider Quadruplex-interacting compounds for regulating the translation of the EpsteinBarr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers Anton Granzhan, Rodrigo Prado Martins, Robin Fahraeus, Marc Blondel and Marie-Paule Teulade-Fichou Click and combinatorial approaches to quadruplex ligand discovery Jyotirmayee Dash, Puja Saha and Khushnood Fatma Quadruplex nucleic acids in KRAS targeted-cancer therapy Luigi E. Xodo Transcriptional regulation of MYC through G-quadruplex structures Sumirtha Balaratnam and John S. Schneekloth KIT promoter: Structure, function and targeting Silvia Ceschi and Claudia Sissi Quadruplex targets in neurodegenerative diseases Janez Plavec Metal complexes as G-quadruplex binders Tim Kench and Ramon Vilar Challenges in developing small-molecule quadruplex therapeutics Stephen Neidle