Rourke, Introduction: The NLD Syndrome and the White Matter Model. Fuerst, Rourke, White Matter Physiology and Pathology. Smith, Rourke, Callosal Agenesis. Klin et al, Apserger Syndrome. Fuerst, Dool, Rourke, Velocardiofacial Syndrome. Anderson, Rourke, Williams Syndrome. Tsatsanis, Rourke, de Lange Syndrome. Fletcher et al., Early Hydrocephalus. Dool, Fuerst, Rourke, Sotos Syndrome. Rovet, Congenital Hypothyroidism. Picard, Rourke, Neuropsychological Consequences of Prophylactic Treatment for Acute Lymphocytic Leukemia. Dool, Fuerst, Rourke, Metachromatic Leukodystrophy. Rovet, Turner Syndrome. Don, Rourke, Fetal Alcohol Syndrome. White, Krengel, Multiple Sclerosis. Ewing-Cobbs, Fletcher, Levin, Traumatic Brain Injury. White, Krengel, Toxicant-Induced Encephalopathy. Tsatsanis, Rourke, Conclusions and Future Directions. Appendix:Rourke, Treatment Program for the Child with NLD.