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Phenotypes and Genotypes Florian Frommlet

Phenotypes and Genotypes By Florian Frommlet

Phenotypes and Genotypes by Florian Frommlet


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Summary

Thistimely text presents a comprehensive guide to genetic association, a new andrapidly expanding field that aims to elucidate how our genetic code (genotypes)influences the traits we possess (phenotypes).

Phenotypes and Genotypes Summary

Phenotypes and Genotypes: The Search for Influential Genes by Florian Frommlet

This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.

About Florian Frommlet

Dr. Florian Frommlet is a researcher in the Center for Medical Statistics, Informatics, and Intelligent Systems at the Medical University of Vienna, Austria.

Dr. Malgorzata Bogdan is an Associate Professor in the Institute of Mathematics at Wroclaw University, Poland.

Dr. David Ramsey is a Senior Lecturer in the Department of Operations Research at Wroclaw University of Technology, Poland.

Table of Contents

Introduction

A Primer in Genetics

Statistical Methods in High Dimensions

Statistical Methods of QTL Mapping for Experimental Populations

Statistical Analysis of GWAS

Appendix A: Basic Statistical Distributions

Appendix B: Basic Methods of Estimation

Appendix C: Principles of Statistical Testing

Appendix D: Elements of Bayesian Statistics

Appendix E: Other Statistical Methods

Additional information

NLS9781447173809
9781447173809
1447173805
Phenotypes and Genotypes: The Search for Influential Genes by Florian Frommlet
New
Paperback
Springer London Ltd
2019-03-20
222
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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