From the reviews:
"This book surveys much of the current research in the area of biological solid-state NMR spectroscopy, and as such should be of great interest to the chemical, biochemical, and biophysical communities. The level is appropriate for graduate students, and the book would be an excellent textbook for a graduate level course in biological solid-state NMR spectroscopy. Its publication is timely considering the recent numerous developments in this area … ." (Michele Auger, Journal of the American Chemical Society, Vol. 129 (10), 2007)
Part I Principles
1. Introduction
2. Solid state NMR approach
2.1. CP-MAS and DD-MAS NMR
2.2. Quadrupolar nuclei
3. Brief outline of NMR parameters
3.1. Chemical shifts
3.2. Relaxation parameters
3.3. Dynamics-dependent suppression of peaks
4. Multinuclear approaches
4.1. 31P NMR
4.2. 2H NMR
4.3. 17O NMR
5. Experimental strategies
5.1. Isotope enrichment (labeling)
5.2. Assignment of peaks
5.3. Ultra high-field and ultra high-speed MAS NMR spectroscopy
6. NMR constraints for structural determination
6.1. Orientational constraint
6.2. Interatomic distance
6.3. Torsion angles
6.4. Conformation-dependent 13C chemical shifts
7. Dynamics
7.1. Fast motions with motional frequency >106 Hz
7.2. Intermediate or slow motions with frequency between 106 and 103 Hz
7.3. Very slow motions with frequency < 103 Hz
Part II Applications
8. Hydrogen bonded systems
8.1. Hydrogen bond shifts
8.2. 2H quadrupolar coupling constant
9. Fibrous proteins
9.1. Collagen fibrils
9.2. Elastin
9.3. Cerial proteins
9.4. Silk fibroin
9.5. Keratin
9.6. Bacteriophage coat protein
10. Polysaccharides
10.1. Distinction of polymorphs
10.2. Network structure, dynamics and gelation mechanism
11. Polypeptides as new materials
11.1. Liquid crystalline polypeptides
11.2. Blend system
12. Globular proteins
12.1. (Almost) complete assignment of 13C NMR spectra of globular proteins
12.2. 3D structure: ?-spectrin SH3 domain
12.3. Ligand-binding to globular protein
13. Membrane protein I: dynamic picture
13.1. Bacteriorhodopsin
13.2. Phoborhodopsin and its cognitive transducer
13.3. Diacylgycerol kinase
14. Membrane proteins II: 3D structure
14.1. 3D structure of mechanically aligned membrane proteins
14.2. Secondary structure based on distance constraints
15. Biologically active membrane-associated peptides
15.1. Channel-forrming peptides
15.2. Antimicrobial peptides
15.3. Opioid peptides
15.4. Fusion peptides
15.5. Membrane model system
17. Amyloid and related biomolecules
17.1. Amyloid ?-peptide
17.2. Calcitonin (CT)