In 2000, the Clay Foundation of Cambridge, Massachusetts, announced a historic competition: Whoever could solve any of seven extraordinarily difficult mathematical problems, and have the solution acknowledged as correct by the experts, would receive $1million in prize money. They encompass many of the most fascinating areas of pure and applied mathematics, from topology and number theory to particle physics, cryptography, computing and even aircraft design. Keith Devlin describes here what the seven problems are, how they came about, and what they mean for mathematics and science. In the hands of Devlin, each Millennium Problem becomes a fascinating window onto the deepest questions in the field.