Part I. Epidemiology/Prevention Biology and Molecular Genetics of Colorectal Cancer Scott K. Kuwada, Deborah W. Neklason, and Randall W. Burt Epidemiological Trends in Colorectal Cancer Susan M. Talbot and Alfred I. Neugut Dietary and Lifestyle Influences on Colorectal Carcinogenesis Charles S. Fuchs Screening and Surveillance Arnold J. Markowitz Chemoprevention of Colorectal Cancer Monica M. Bertagnolli Management of Hereditary Colon Cancer Syndromes Miguel A. Rodriguez-Bigas and Nicholas J. Petrelli Part II. Diagnostic and Therapeutic Radiology Overview of CT, MRI, and Ultrasound in the Imaging and Staging of Colorectal Cancer David J. Vining Virtual Colonoscopy for Colorectal Cancer Screening and Surveillance David T. Rubin and Abraham H. Dachman Preoperative Staging of Rectal Cancer: Endorectal Ultrasound and Endorectal MRI Spiros Hiotis, Sharon Weber, and W. Douglas Wong Nuclear Medicine in the Diagnosis and Management of Colorectal Cancer Stanley J. Goldsmith and Lale Kostakoglu Radiation Therapy of Resectable Rectal Cancer Nora A. Janjan, Matthew Ballo, Christopher Crane, and Marc Delclos Management of Locally Unresectable Rectal Cancer Bruce D. Minsky Radiation Therapy for Hepatic Metastases John M. Robertson Part III. Surgery of Colorectal Cancer Surgical Pathology of Colorectal Cancer Carolyn C. Compton Surgery of Colon Cancer Alfred T. Culliford IV and Philip B. Paty Laparoscopy in Colorectal Cancer Management Heidi Nelson and Bernardo Tisminezky Management of Cancer in a Polyp David A. Rothenberger and Julio Garcia-Aguilar Surgery of Rectal Cancer Aaron R. Sasson and Elin R. Sigurdson Conservative Management of Early-Stage Rectal Cancer Mitchell C. Posner and Glenn D. Steele, Jr. Surgical Management of Hepatic Colorectal Metastases William R. Jarnagin and Yuman Fong Resection of Colorectal Metastases to the Lung Robert J. Downey Surgical Management of Peritoneal Surface Spread of Colorectal Cancer Paul H. Sugarbaker Cryosurgical Ablation for the Management of Unresectable Hepatic Colorectal Metastases Gregory D. Kennedy, Fred T. Lee, Jr., David Mahvi, and John E. Niederhuber Radiofrequency Ablation of Colorectal Metastases to the Liver Douglas L. Fraker Part IV. Medical Oncology 5-Fluorouracil and Its Biomodulation in the Management of Colorectal Cancer Jean L. Grem Clinical Implications of Dihydropyrimidine Dehydrogenase on 5-Fluorouracil Pharmacology Robert B. Diasio Oral Fluoropyrimidines in Colorectal Cancer John L. Marshall Irinotecan in the Treatment of Colorectal Cancer Leonard B. Saltz Oxaliplatin in the Treatment of Colorectal Cancer Stacy D. Jacobson, Steven R. Alberts, and Richard M. Goldberg TS Inhibitors and Antifolates Hugo E. R. Ford and David Cunningham Adjuvant Therapy for Colon Cancer Kyle Holen and Leonard B. Saltz Hepatic Artery Infusion M. Margaret Kemeny and Nancy E. Kemeny Intraportal and Intraperitoneal Chemotherapy for Colon Cancer Werner Scheithauer Molecular Markers of Chemotherapy Resistance in Colorectal Cancer Peter V. Danenberg Part V. Supportive Management Cancer Pain Syndromes in Colorectal and Anal Cancers Nathan I. Cherny Pain Management in Colorectal and Anal Cancers Nathan I. Cherny Sexuality and Fertility in Patients with Colorectal Cancer Megan P. Fleming Complementary and Alternative Medicine Approaches in Colorectal Cancer Andrew J. Vi