Name: Cardiac Mechano-Electric Feedback and Arrhythmias By Peter Kohl
SKU: 9781416000341
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Cardiac Mechano-Electric Feedback and Arrhythmias Summary

Cardiac Mechano-Electric Feedback and Arrhythmias by Peter Kohl

Better understand the mechanisms of arrhythmia, cellular modifiers, and the clinical answers to these disorders! Written by internationally recognized leaders in the field, this groundbreaking resource reflects the state of the art in all aspects of mechanical heart function. Readers will find detailed discussions of mechanisms of feedback; effects on cellular electrophysiology; experimental manifestations; normal physiology; pathogenic mechanisms; therapeutic interventions; and, more.

Introduction * Cardiac mechano-electric interactions and the induction & termination of arrhythmia Fundamental Mechanisms of Cardiac Mechano-Electric Feedback * Cardiac non-selective stretch-activated cation channels: pathophysiological potential * Mechanical modulation of cardiac potassium channels * Cell-volume activated ion channels in cardiac cells * Contribution of cytoskeleton and lipid bi-layer to cellular mechano-reception * The response of cardiac muscle to stretch: role of calcium * Stretch-effects on second messengers and early gene expression Cellular Effects of Mechano-Electric Feedback * Differential effects of stretch on cardiac cells in diastole and systole * Differential effects of stretch and compression of cardiac cells * Mechanical modulation of cardiac non-myocyte structure and function * Mechanical effects on auto- & paracrine signalling in cardiac myocytes and non-myocytes * Stretch effects on connexin expression in cardiac cells Mechano-Electric Feedback in Cardiac Tissue and Whole Heart * Mechanical modulation of sino-atrial pacemaking rate * Stretch effects on atrial conduction and refractoriness * Stretch effects on ventricular conduction and refractoriness * Neuro-humoral modulation of cardiac mechano-electric interactions * Mechanically-induced repolarization dispersion and the mechanical vulnerable period * Experimental arrhythmogenesis by acute mechanical stimulation (Commotio cordis) * Specific stretch-channel blockers: a new class of anti-arrhythmic drugs Clinical Evidence for Cardiac Mechano-Electric Feedback in Man * Non-neuronal component of respiratory sinus arrhythmia * Induction of arrhythmias by precordial impact * Arrhythmogenesis during cardiac catheterisation * Role of transmural gradients in mechano-electric interactions * Hemodynamic unloading and termination of arrhythmias * Bypass-induced ventricular load changes and action potential configuration * Termination of ventricular arrhythmia by acute mechanical interventions Clinical Relevance of Cardiac Mechano-Electric Feedback * Cardiac mechanics and the ECG U-wave * Arrhythmias in ischaemic heart disease in linkage with regional wall motion abnormalities * Arrhythmogenic potential of dysynergy of ventricular mechanics in patients with heart failure and wide QRS complex * Bi-ventricular pacing as a new treatment modality to restore ventricular synchronization * Atrial fibrillation in dilated cardiomyopathy * The angiotensin-renin pathway in left ventricular hypertrophy and SCD * Volume and pressure overload and ventricular arrhythmogenesis * Mortality from heart failure: haemodynamic versus electrical causes * Passive ventricular constraint: new treatment concept for dilated cardiomyopathy * Mechanical modulation of defibrillation efficacy by preload changes * Mechanical advances in cardiopulmonary resuscitation Clinical Trials Evaluating Survival Benefits by Ventricular Unloading or Resynchronization * Effects of bi-ventricular pacing on cardiac mortality and arrhythmias - the Companion trial * InSync Trial * Counter-pulsation and cardiac assist devices. * New intra-ventricular chamber reduction devices (Percutaneous catheter mediated endocardial ventriculoplasty for patients with heart failure). * Ventricular restraint study and reverse re-modeling in patients. * Evolving concepts in measuring ventricular stress-strain relations in the human heart Index

Additional information

Sku

GOR012392769

ISBN 13

9781416000341

ISBN 10

1416000348

Title

Cardiac Mechano-Electric Feedback and Arrhythmias by Peter Kohl

Author

Peter Kohl

Condition

Used - Very Good

Binding type

Hardback

Publisher

Elsevier - Health Sciences Division

Year published

20050415

Number of pages

448

Prizes

N/A

Cover note

Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

Note

This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in very good condition, but if you are not entirely satisfied please get in touch with us

Cardiac Mechano-Electric Feedback and Arrhythmias Peter Kohl

Cardiac Mechano-Electric Feedback and Arrhythmias by Peter Kohl

Summary

Cardiac Mechano-Electric Feedback and Arrhythmias Summary

Cardiac Mechano-Electric Feedback and Arrhythmias by Peter Kohl

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