Preface. List of Contributors. XVI Lorenzini Annual Lecture. Estrogen Receptor beta - A Multifaceted Player; J.-A. Gustafsson. XVII Lorenzini Annual Lecture. Andropause at the Beginning of the New Century: A Few Remarks on Hormones and Aging of Men; E.-E. Baulieu. Bone and Joints. 1. Mechanisms of Estrogen Regulation of Bone Turnover and Bone Mass; B.L. Riggs. 2. Genetics of Osteoporosis; L. Gennari, et al. 3. The Intrauterine Programming of Osteoporosis; C. Cooper, et al. 4. The Role of Menopause in Bone and Joint Health: Implications for Osteoarthritis and Osteoporosis; M.F. Sowers. Osteoporosis Prevention Utilizing Novel Compounds. 5. Novel Compounds Acting Through Receptors and Enzyme Mediators; T.M. Penning. 6. Tibolone Is Effective in Preventing Postmenopausal Bone Loss; J.C. Gallagher. Immune System and Inflammation. 7. Sex Hormones and the Immune System: Implications for Menopause and Autoimmunity; G. Mor. Hormone Replacement Therapy. 8. Routes of HRT Administration. When to Use Oral Or Transdermal Administration; G. Samsioe. 9. The Role of Antiandrogens in Peri- and Postmenopausal HRT; H.P.G. Schneider. Sex Steroids and Reproduction. 10. Sex Steroid-Sensitive Reproductive Tissues in Women During Reproduction and Menopause; F. Naftolin, et al. Cardiovascular Disease. 11. Does Menopause Increase the Incidence of Coronary Heart Disease? Y.T. van der Schouw. 12. Reducing Cardiovascular Risk in Postmenopausal Women: Estrogen or Statins? R.O. Cannon. 13. Effects of Estrogen Replacement in Women with Coronary Disease; D.M. Herrington, K.P. Klein. HRT and Cardiovascular Disease: A New Approach. 14. Recent Findings in Cardiovascular Disease; R.A. Lobo. 15. Hormone Replacement and Cardiovascular Disease; K.C. Johnson. 16. The Role of Potassium; P. Kowey. 17. Aldosterone-Receptor Blocking Agents; B. Pitt. 18. Progestogens: New Approaches; R.A. Lobo. Cancer. 19. Aromatase, Nuclear Receptors, Adipose Tissue, And Breast Cancer; E.R. Simpson, et al. 20. Environmental Factors Related to Cancers in Postmenopausal Women; L.A. Brinton. 21. Growth Factors and Cancer &endash; The Role of Insulin-Like Growth Factors; H. Yu. 22. Postmenopausal Hormone Use and Endometrial Cancer: Reassessment of the Epidemiological Data; G.A. van Unnik, et al. 23. Hormone Replacement Therapy and Breast Cancer: Still More ore Questions Than Answers; S. Love. 24. Hormonal Approach to Breast Cancer Prevention and Treatment; J. Russo, I.H. Russo. Emerging Directions in Menopause Management: Lowering HRT Doses. 25. Healthy Postmenopausal Women Receiving HRT Are Not a Risk for Early Coronary Events: Results from 2 Large Clinical Trials; G.D. Constantine, et al. 26. Oral Contraceptive Use and Risk of Low Bone Density in Women Attending Menopause Clinics in Italy; C. Donati Sarti, et al. Stress Incontinence. 27. Less Invasive Surgery in Stress Incontinence; J. Bidmead, L. Cardozo. Central Nervous System and Mood Disorders. 28. An Overvi