The value of radioisotopes to biological research is undisputed. Without their availability and use we would be ignorant of a vast range of physiological and biochemical processes, including intermediatary metabolism, neurochemistry, hormone action and protein synthesis. The range and detail of applications is vast and beyond the scope of any book. However, there are general principles and techniques common to all or most radiotracer experiments: in the first place, the decisions to use then chose a radioisotope; secondly, the establishment of a suitable working environment conducive to safe laboratory practice and the compliance with relevant legislation; thirdly, the principles of safe and efficient experimental design, and finally the radiation detection and data analysis. These features, essential to any radioisotope experiment, are fully explored in this book. explores these