BASIC PRINCIPLES AND CONSIDERATIONS OF RATIONAL CHEMOTHERAPY Biologic and Pharmacologic Basis of Cancer Chemotherapy and Biotherapy Roland T. Skeel and Samir N. Khleif Systemic Assessment of the Patient with Cancer and Long Term Consequences of Treatment Roland T. Skeel Selection of Treatment for the Patient with Cancer Roland T. Skeel CHEMOTHERAPEUTIC AND BIOTHERAPEUTIC AGENTS AND THEIR USE Antineoplastic Drugs and Biologic Response Modifiers: Classification, Use, and Toxicity of Clinically Useful Agents Roland T. Skeel High Dose Chemotherapy with Progenitor Cell and Cytokine Support Roberto Rodriguez and Chatchada Karanes CHEMOTHERAPY OF HUMAN CANCER Carcinomas of the Head and Neck Harlan Pinto Carcinoma of the Lung Sophie Sun and Joan H. Schiller Carcinomas of the Gastrointestinal Tract Al B. Benson, III Carcinomas of the Pancreas, Liver, Gallbladder, and Bile Ducts Rekha Chaudhary Carcinoma of the Breast Iman Mohamed Gynecologic Cancer Stephen Andrews Urologic and Male Genital Cancers Joseph S. Chan, Scott B. Saxman, and Craig R. Nichols Kidney Cancer Walter D.Y. Quan and Mikhail Vinogradov Thyroid and Adrenal Carcinomas Haitham S. Abu-Lebdeh and Samir N. Khleif Melanomas and Other Skin Malignancies Karen S. Milligan and Walter D.Y. Quan Primary and Metastatic Brain Tumors April L. Fitzsimmons and Tracy T. Batchelor Soft Tissue Sarcomas Robert S. Benjamin Bone Sarcomas Robert S. Benjamin Acute Leukemias Olga Frankfurt and Martin S. Tallman Chronic Leukemias Peter White and Paul Walker Myeloproliferative and Myelodysplastic Syndromes Peter White and Paul Walker Hodgkin's Lymphoma Richard S. Stein and David S. Morgan Non-Hodgkin's Lymphoma Richard S. Stein and John P. Greer Multiple Myeloma, Other Plasma Cell Disorders, and Primary Amyloidosis Mohamed Hussein Metastatic Cancer of Unknown Origin James M. Leonardo HIV-Associated Malignancies Mary Cianfrocca Side Effects of Cancer Chemotherapy Janelle M. Tipton SELECTED ASPECTS OF SUPPORTIVE CARE OF PATIENTS WITH CANCER Infections: Etiology, Treatment, and Prevention Joan M. Duggan Transfusion Therapy, Bleeding, and Clotting Mary R. Smith and NurJehan Quraishy Oncology Emergencies and Critical Care Issues: Anaphylaxis, Spinal Cord Compression, Cerebral Edema, Superior Vena Cava Syndrome, Hypercalcemia, Tumor Lysis Syndrome, and Respiratory Failure Roland T. Skeel Malignant Pleural, Peritoneal, and Pericardial Effusions and Meningeal Infiltrates Rekha Chaudhary Cancer Pain Michael Fisch and Charles Cleeland Emotional and Psychiatric Problems in Patients with Cancer Kathleen S.N. Franco-Bronson and Kristi S. Williams
