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Genomics, Circuits, and Pathways in Clinical Neuropsychiatry Thomas Lehner (National Institutes of Mental Health, Rockville, MD, USA)

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry By Thomas Lehner (National Institutes of Mental Health, Rockville, MD, USA)

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by Thomas Lehner (National Institutes of Mental Health, Rockville, MD, USA)


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Genomics, Circuits, and Pathways in Clinical Neuropsychiatry Summary

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by Thomas Lehner (National Institutes of Mental Health, Rockville, MD, USA)

This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.

About Thomas Lehner (National Institutes of Mental Health, Rockville, MD, USA)

Dr. Thomas Lehner is the Director of the Office for Genomics Research Coordination at the National Institute of Mental Health (NIMH), National Institutes of Health (NIH). He oversees and coordinates all efforts associated with genomics research for the NIMH and is the principal advisor to the NIMH Director and the NIMH Scientific Director for issues related to genetics and genomics. A native of Vienna, Austria, he received a Ph.D. in genetics from the University of Vienna and an MPH in Epidemiology from Columbia University. Since joining NIMH in 2004 Thomas has been instrumental in developing Team Science as a new paradigm for psychiatric genomics and forging international collaborative efforts and consortia. He has also been instrumental in developing and consolidating genomics resources for the research community through participation in developing NIH data sharing policies for genomics including the Genomic Data Sharing (GDS) policy and its implementation. Dr. Miller holds the A.W. and Mary Margaret Clausen Distinguished Professorship in Neurology at the University of California, San Francisco (UCSF). He directs the busy UCSF dementia center where patients in the San Francisco Bay Area and beyond receive comprehensive clinical evaluations. His goal is the delivery of model care to all of the patients who enter the clinical and research programs at the UCSF Memory and Aging Center (MAC). Dr. Miller is a behavioral neurologist focused on dementia with special interests in brain and behavior relationships as well as the genetic and molecular underpinnings of disease. His work in frontotemporal dementia (FTD) emphasizes both the behavioral and emotional deficits that characterize these patients, while simultaneously noting the visual creativity that can emerge in the setting of FTD. He is the principal investigator of the NIH-sponsored Alzheimers Disease Research Center (ADRC) and program project on FTD called Frontotemporal Dementia: Genes, Imaging and Emotions. He oversees a healthy aging program, which includes an artist in residence program. In addition, he helps lead two philanthropy-funded research consortia, the Tau Consortium and Consortium for Frontotemporal Research, focused on developing treatments for tau and progranulin disorders, respectively. Also, he works with the National Football League to help with the education and assessment of players related to brain health. Dr. Miller teaches extensively, runs the Behavioral Neurology Fellowship at UCSF, and oversees visits of more than 50 foreign scholars every year. Dr. Miller has received many awards including the Potamkin Award from the American Academy of Neurology, the Raymond Adams Lecture at the American Neurological Association, the Elliot Royer Award from the San Francisco Neurological community, the UCSF Annual Faculty Research Lectureship in Clinical Science, the UCSF Academic Senate Distinction in Mentoring Award, Distinguished Service to Minorities, from Charles Drew University, and the Gene D. Cohen Research Award in Creativity and Aging from the National Center for Creative Aging. He has authored The Human Frontal Lobes, The Behavioral Neurology of Dementia, Frontotemporal Dementia and over 600 other publications regarding dementia. He has been featured in Fortune magazine and The New York Times, as well as on "Charlie Rose," "PBS NewsHour" and other media. For more than three decades, Dr. Miller has been the scientific director for the philanthropic organization The John Douglas French Alzheimers Foundation, a private philanthropic organization that funds basic science research in Alzheimers disease. Matthew W. State MD, PhD, is a child psychiatrist and human geneticist studying pediatric neuropsychiatric syndromes. His lab focuses on gene discovery as a launching point for efforts to illuminate the biology of these conditions and to develop novel and more effective therapies. Dr. State received his undergraduate and medical degrees at Stanford University, completed his residency in psychiatry and fellowship in child psychiatry at the UCLA Neuropsychiatric Institute, and earned a PhD in genetics from Yale University. He was on the faculty at Yale from 2001 to 2013 where he was the Donald J. Cohen Professor of Child Psychiatry, Psychiatry and Genetics and the Co-Founder and Co-Director of the Yale Program on Neurogenetics. He is currently the Oberndorf Family Distinguished Professor and Chair of Psychiatry at UCSF and Director of the Langley Porter Psychiatric Institute and Hospital.

Table of Contents

Section 1 The Genome Tools and Methods 1. The Newly Emerging View of the Genome Stephan Sanders 2. Genetic Epidmeiology Kathleen Ries Merikangas 3. Common Variation Mark Daly 4. Rare/Structural Variation Daniel Barrera and Jonathan Sebat 5. Epigenetics and Epigenomics Eric J. Nestler and John Greally 6. Bioinformatics Shaun Purcell 7. Imaging Genomics Paul Matthew Thompson 8. Stem Cell Technology and Genomics Alysson Renato Muotri 9. Association Strategies Benjamin M. Neale 10. The promise of Systems Biology Eric Schadt 11. Gene networks in neuropsychiatric disease Daniel Geschwind 12. Mosaicism Christopher A. Walsh and Saumya Shekhar Jamuar Section 2 A new neuroanatomy 13. Mapping the Molecular Landscape of the Human Brain Nenad Sestan 14. Studying Circuits Stephan Lammel and Robert Malenka 15. Electrophysiological Measurement of Circuits Srikantan S. Nagarajan 16. Imaging the Circuitry of the Human Brain Michael Greicius 17. Neuroimaging Advances in Alzheimers Disease Daniel R. Schonhaut and Gil Rabinovici 18. Progressive Supranuclear Palsy and Related Parkinsonian Disorders Jesse A. Brown and William Seeley 19. The Anatomy of Basal Ganglia Circuitry of Behavior Nicholas Au Yong, Adrienne M. Keener, Yvette Bordelon, Carlos Portera-Cailliau and Nader Pouratian 20. Brainstem Circuitry of Behavior Helmut Heisen 21. Apathy Basal Ganglia, Frontal Circuits Mario F. Mendez 22. Emotion Circuitry Robert Wayne Levenson 23. Delusions Georges Naasan 24. Hallucinations Dennis Velakoulis Section 3 Clinical Phenomenology 25. Intro: Risk Overlap Among Disorders Patrick Sullivan 26. The conundrum of Clinical Characterization RDOC/ICD-10/DSM Bruce N. Cuthbert 27. Schizophrenia Aiden Corvin 28. Psychosis Raquel E. Gur and Ruben Gur 29. ASD Rebecca Ann Muhle, Stephan Sanders, Hannah Reed and Matthew William State 30. Bipolar Disorder Nelson B. Freimer, Carrie E. Bearden and Peter Zandi 31. MDD David C. Glahn 32. Speech and Language Disorders Marilu Gorno-Tempini 33. Molecular Pathways Leading to the Clinical Phenomenology of Frontotemporal Dementia Suzee Eurie Lee and Jennifer S. Yokoyama 34. Alzheimers Rudy Tanzi 35. PTSD Kerry Ressler 36. Neurodevelopmental syndromes Elliott Sherr 37. Epilepsies Ryan S. Dhindsa, Daniel Lowenstein and David Goldstein 38. Substance Abuse Nii Addy 39. Neuroimmunology Emmanuel Mignot 40. Brain Tumors Vanessa Clark and Murat Gunel 41. White Matter Disorders Michael David Geschwind and Brianne Magouirk Bettcher 42. ALS Elena Ratti and James Berry 43. Eating Disorders Cynthia M. Bulik and Garret Stuber Section 4 Clinical Translation and Drug Development 44. Pharmacogenomics Roy H. Perlis

Additional information

NPB9780128001059
9780128001059
0128001054
Genomics, Circuits, and Pathways in Clinical Neuropsychiatry by Thomas Lehner (National Institutes of Mental Health, Rockville, MD, USA)
New
Hardback
Elsevier Science Publishing Co Inc
2016-06-23
796
N/A
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