This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors.

The structure of the adenosine receptors: implications for drug discovery J. Robert Lane, Veli-Pekka Jaakola, Adriaan P. IJzerman Adenosine Receptors in Health and Disease Stefania Gessi, Stefania Merighi, Katia Varani, and Pier Andrea Borea Adenosine and the Regulation of Metabolism and Body Temperature Bertil Fredholm, Stina M. Johansson and Ying-Qing Wang Regulation of Leukocyte Function by Adenosine Receptors Joel Linden Role of Adenosine A2B Receptors in Inflammation Igor Feoktistov and Italo Biaggioni Interplay of Hypoxia and A2B Adenosine Receptors in Tissue Protection Michael Koeppen, Tobias Eckle, and Holger Eltzschig Allosteric Modulation of Purine and Pyrimidine Receptors Kenneth Jacobson, Zhan-Guo Gao, Aniko Goblyos, and Adriaan IJzerman Molecular Mechanisms of Purine and Pyrimidine Nucleotide Release Eduardo R. Lazarowski, Juliana I. Sesma, Lucia Seminario-Vidal, and Silvia M. Kreda Impact of Ectoenzymes on Purinergic Signalling Filip Kukulski, Sebastien A. Levesque, and Jean Sevigny Ectonucleotidases as Regulators of Purinergic Signaling in Inflammation and Thrombosis Simon C. Robson and Silvia Deaglio P2X Receptors in Health and Disease Geoffrey Burnstock and Charles Kennedy Molecular Pharmacology, Physiology, and Structure of the P2Y Receptors Ivar von Kugelgen and T. Kendall Harden2 P2Y Receptors in Health and Disease David Erlinge P2 Receptor Signaling in Neurons and Glia of the Central Nervous System Laszlo Koles Anna Leichsenring, Patrizia Rubini and Peter Illes Role of Purinergic Receptors in Neuroprotection Tozaki-Saitoh Hidetoshi, Makoto Tsuda, and Kazuhide Inoue