Name: Principles of Clinical Pharmacology By Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)
SKU: 9780120660605
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Principles of Clinical Pharmacology Summary

Principles of Clinical Pharmacology by Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

The rate of introduction of new pharmaceutical products has increased rapidly over the past decade, and details learned about a particular drug become obsolete as it is replaced by newer agents. Principles of Clinical Pharmacology focuses on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. The coverage of these principles in this book will be of particular benefit to individuals engaged either in the teaching or study of sound therapeutic technique or in the investigation of pharmacological agents.

Principles of Clinical Pharmacology Reviews

...this book fulfills the long-felt need for an updated publication in Clinical Pharmacology. --INDIAN JOURNAL OF PHARMACOLOGY (2003)...this book is for the reader who wants a detailed in- depth understanding of clinical pharmacology. --E STREAMS (2003)

About Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

Arthur J. Atkinson, Jr., M.D., M.A.C.P., is Adjunct Professor of Pharmacology at the Feinberg Medical School of Northwestern University. He has held leadership roles in clinical pharmacology for more than 50 years, working in both academia and the pharmaceutical industry, and for NIH. He founded and for 24 years directed a Clinical Pharmacology Center at Northwestern, rising to the rank of Professor of Pharmacology and Medicine. He was subsequently Corporate Vice President for Clinical Development and Medical Affairs at the Upjohn Company. Following the Upjohn-Pharmacia merger, he was recruited to be Senior Advisor in Clinical Pharmacology at the NIH Clinical Center. There, he initiated a clinical pharmacology course and served as lead editor for the previous three editions of Principles of Clinical Pharmacology, the required text for the course. Dr. Atkinson has been elected Master of the American College of Physicians and to membership in the American Association of Physicians. He received the Harry Gold Award from ASPET, the Oscar Hunter Award from ASCPT, and the Award in Excellence from the PhRMA Foundation.

IntroductionPART 1: PHARMACOKINETICS:Clinical pharmacokinetics.Compartmental analysis of drug distribution.Drug absorption and bioavailability.Effects of renal disease on pharmacokinetics.Kinetics of hemodialysis and hemofiltration.Effects of liver disease on pharmacokinetics.Noncompartmental vs. compartmental approaches to pharmacokinetic analysis.Distributed models of drug kinetics.Population pharmacokinetics. PART 2: DRUG METABOLISM AND TRANSPORT:Pathways of drug metabolism.Chemical assay of drugs and drug metabolites.Pharmacogenetics.Drug interactions.Biochemical mechanisms of drug toxicity.Equilibrative and concentrative transport. PART 3: ASSESSMENT OF DRUG EFFECTS:Physiological and laboratory markers of drug effect.Dose response and concentration response analysis.Kinetics of pharmacologic effect.Disease progression models.PART 4: OPTIMIZING AND EVALUATING DRUG THERAPY:Sex differences in pharmacokinetics and pharmacodynamics.Drug therapy in pregnant and nursing women.Drug therapy in neonates and pediatric patients.Drug therapy in the elderly.Clinical analysis of adverse drug reactions.Quality assessment of drug therapy.PART 5: DRUG DISCOVERY AND DEVELOPMENT:Project management.Drug discovery.Pre-clinical development.Animal scale up.Phase I studies.PK and PD considerations in the development of biotechnology products and large molecules. Design of clinical development programs.Role of the FDA in guiding drug development.Appendix I: Table of Laplace TransformsAppendix II: Answers to Study Problems

Additional information

Sku

CIN0120660601G

ISBN 13

9780120660605

ISBN 10

0120660601

Title

Principles of Clinical Pharmacology by Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

Author

Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

Condition

Used - Good

Binding type

Hardback

Publisher

Elsevier Science Publishing Co Inc

Year published

20010921

Number of pages

480

Prizes

N/A

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Book picture is for illustrative purposes only, actual binding, cover or edition may vary.

Note

This is a used book - there is no escaping the fact it has been read by someone else and it will show signs of wear and previous use. Overall we expect it to be in good condition, but if you are not entirely satisfied please get in touch with us

Principles of Clinical Pharmacology Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

Principles of Clinical Pharmacology by Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

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Principles of Clinical Pharmacology Summary

Principles of Clinical Pharmacology by Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

Principles of Clinical Pharmacology Reviews

About Arthur J. Atkinson Jr. (Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States)

Table of Contents

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