Preface to the Third Edition 6
Preface to the First Edition 7
Part 1 Fundamentals
1. Introduction 8
2. Chemical transmission 10
3. Mechanisms of hormone action: I Membrane receptors 12
4. Mechanisms of hormone action: II Intracellular receptors 14
5. The hypothalamus and pituitary gland 16
6. Gonadotrophin-releasing hormone: a peptide hormone 18
7. Principles of feedback control 20
8. Endocrine function tests 22
Part 2 Growth
9. Growth: I Cellular growth factors 24
10. Growth: II Normal growth 26
11. Growth: III Growth hormone 28
12. Growth: IV Pathophysiology 30
Part 3 Thyroid
13. Thyroid: I Thyroid gland and thyroid hormones 32
14. Thyroid: II Thyroid hormone secretion and action 34
15. Thyroid: III Thyroid pathophysiology 36
Part 4 Adrenals and Autoimmunity
16. Adrenal gland: I Adrenal medulla 38
17. Adrenal gland: II Adrenocortical hormones 40
18. Adrenal gland: III Adrenocorticotrophic hormone (ACTH) 42
19. Adrenal gland: IV Cortisol and androgens 44
20. Adrenal gland: V Aldosterone 46
21. Adrenal gland: VI Pathophysiology 48
22. Endocrine autoimmunity 50
Part 5 Sexual Differentiation and Development
23. Sexual differentiation and development: I Introduction 52
24. Sexual differentiation and development: II Puberty 54
Part 6 Female Reproduction
25. Female reproduction: I Menstrual cycle 56
26. Female reproduction: II Ovarian steroids 58
27. Female reproduction: III Pregnancy 60
28. Female reproduction: IV Parturition and lactation 62
29. Female reproduction: V Pathophysiology 64
30. Female reproduction: VI Contraception 66
Part 7 Male Reproduction
31. Male reproduction: I The testis 68
32. Male reproduction: II Actions of androgens 70
33. Male reproduction: III Pathophysiology 72
Part 8 Posterior Pituitary Hormones, Salt and Water Balance and Hypertension
34. Oxytocin 74
35. Vasopressin 76
36. Reninangiotensinaldosterone system 78
37. Endocrine hypertension 80
Part 9 Metabolic Endocrinology: Pancreas and Gastrointestinal Tract
38. Insulin: I The pancreas and insulin secretion 82
39. Insulin: II Insulin action 84
40. Insulin: III Type 1 diabetes mellitus 86
41. Insulin: IV Type 2 diabetes mellitus 88
42. Glucagon 90
43. Gastrointestinal hormones 92
Part 10 Metabolic Endocrinology: Energy Homoeostasis and Obesity
44. Energy homoeostasis: I Summary 94
45. Energy homoeostasis: II Central control 96
46. Obesity: I Causes of obesity 98
47. Obesity: II Cardiovascular and respiratory complications 100
48. Obesity: III Insulin resistance and endocrine complications 102
Part 11 Calcium and Metabolic Bone Disease
49. Calcium: I Parathyroid hormone 104
50. Calcium: II Calcitonin 106
51. Calcium: III Vitamin D 108
52. Bone remodelling 110
53. Metabolic bone disease: I Pagets disease 112
54. Metabolic bone disease: II Primary osteoporosis 114
55. Metabolic bone disease: III Secondary osteoporosis 116
Part 12 Self Assessment
MCQs 118
Answers 133
Appendix: Normal Values 136
Glossary 137
Index 139