1. Introduction: Narratives of OCD - Elias Aboujaoude and Christopher Pittenger Section 1: Clinical Presentation and Diagnosis 2. Clinical Presentation of OCD - Fred Penzel 3. Pediatric OCD: Clinical Course, Phenomology, and Assessment - Rachel E. Ginsberg, Samantha Morrison, and Anthony Puliafico 4. Epidemiology, Comorbidity, and Burden of OCD - Albina R. Torres, Leonardo F. Fontenelle, Roseli G. Shavitt, Marcelo Q. Hoexter, Christopher Pittenger, and Euripedes C. Miguel 5. Natural History and Long-Term Outcome of OCD - Michael H. Bloch 6. Quality of Life and Psychosocial Functioning in OCD - Christina L. Boisseau, Carly M. Schwartzman, and Steven A. Rasmussen 7. Psychodynamic perspectives on OCD - Robert A. King Section 2: Phenomenology and Cognitive Psychology 8. Symptom heterogeneity in OCD: A dimensional approach - Maria Concei Conceicao do Rosario, Marcelo Batistutto, and Ygor Ferrao 9. Incompleteness and harm avoidance - Stefano Pallanti, Jennifer Barnes, Christopher Pittenger, and Jane Eisen 10. Disgust and OCD - Lauren Mancusi & Dean McKay 11. Sensory Processing and Intolerance in OCD - Stephanie J. Grimaldi, and Emily R. Stern 12. Scrupulosity and Slowness in OCD: Perfectionism as a Central Mechanism - Rachel Ojserkis and Dean McKay 13. Variable Insight in OCD - Rebecca J. Hamblin, Jennifer Moonjung Park, Monica S. Wu, and Eric A. Storch 14. Clinical Rating Scales for OCD - Joseph F. McGuire, Eric A. Storch, and Wayne Goodman 15. Neuropsychosocial Function in OCD - Amitai Abramovitch 16. Habits and Goals in OCD - Claire M. Gillan 17. Intolerance of Uncertainty in Obsessive-Compulsive Disorder - Ryan J. Jacoby and Jonathan S. Abramowitz 18. Pathological responsibility, thought-action fusion, and thought control in OCD - Christine Purdon Section 3: Biological Underpinnings 19. Genetics Of OCD - Paul Arnold 20. Neurocircuitry underlying OCD : neural networks underlying reward and action selection - Suzanne N. Haber 21. A review and synthesis of functional neuroimaging studies of OCD - Brian P. Brennan and Scott L. Rauch 22. Functional Imaging Studies of OCD: A Hypothesis-Driven Review - M.M. Vaghi and T.W. Robbins 23. The Structure of the OCD Brain - Premika S.W. Boedhoe and Odile A. van den Heuvel 24. Brain Functional Connectivity in OCD - Carles Soriano-Mas and Ben J. Harrison 25. Neurotransmitter dysregulation in OCD - Ilse Graat, Martijn Figee, and Damiaan Denys 26. Neuropeptides in OCD - Anahid Kabasakalian, Eric Hollander 27. Influence of sex hormones on OCD - Valeria Guglielmi, Judith Souget, Wouter van Elzelingen, Ingo Willuhn, and Nienke Vulink 28. PANDAS as a Post-Streptococcal Autoimmune Neuropsychiatric Form of OCD - Susan E. Swedo, Kyle A. Wiliams Section 4: Animal Studies 29. Animal models of OCD: A conceptual framework - Christopher Pittenger, Stephanie Dulawa, and Summer L. Thompson 30. Extinction of conditioned fear and avoidance: Relevance for OCD - Jose Rodriguez-Romaguera and Gregory J. Quirk 31. OCD as a failure to integrate goal-directed and habitual action control - Laura Bradfield, Richard Morris, and Bernard W. Balleine 32. Spontaneously Occurring Animal Models of OCD - Nicholas H. Dodman and Louis Shuster 33. Mutant Mouse Models of OCD - Louis Y. Tee and Guoping Feng 34. Targeted circuit manipulations in the modeling of OCD - Susanne E. Ahmari 35. Pharmacological and behavioral rodent models of OCD - Summer L. Thompson and Stephanie C. Dulawa Section 5: Treatment 36. Overview of the treatment of OCD - H. Blair Simpson 37. Exposure and Response Prevention in OCD - Jonathan S. Abramowitz 38. Cognitive Therapy for OCD - Maureen Whittal 39. Mindfulness and Acceptance Therapies for Obsessive-Compulsive and Related Disorders - Kate L. Morrison, Brooke M. Smith, and Michael P. Twohig 40. Standard Evidence-Based Pharmacological Treatment for OCD - Jemma E. Reid, Samar Reghunandanan, Ann Roberts, and Naomi A. Fineberg 41. The pharmacological treatment of refractory OCD - Christopher Pittenger 42. Treatment of Pediatric OCD - S. Evelyn Stewart and Clare Bleakley 43. Family accommodation in OCD: Prevalence, impact, and clinical implications - Kristin Koller and Eli R. Lebowitz 44. Nutraceutical and alternative treatments for Obsessive compulsive and Related Disorders - David Camfield and Jerome Sarris 45. Functional Neurosurgery in Severe and Treatment-Refractory OCD - Erica C. Keen, Alik S. Widge, and Darin D. Dougherty 46. Deep Brain Stimulation for Intractable OCD - Wayne K. Goodman, Nigel Kennedy, Kyle Lapidus, and Brian H. Kopell 47. Intensive Treatment Approaches for OCD - Joshua M. Nadeau, Bradley C. Riemann, and Eric Storch Section 6: OCD-Related Disorders 48. Obsessive-Compulsive and Related Disorders: A New Category in DSM-5 - Katharine A. Phillips 49. Clinical Features, Assessment, and Treatment of body Dysmorphic Disorder - Lisa Zakhary, Hilary Weingarden, Alexandra Sullivan, and Sabine Wilhelm 50. Body Dysmorphic Disorder: Neurobiology and Genetics - Jamie D. Feusner and Danyale McCurdy-McKinnon 51. Trichtillomania and skin picking disorder - Jon E. Grant, Sarah A. Redden, Eric W. Leppink 52. Hoarding Disorder: Clinical presentation and treatment - Randy O. Frost, Lucy Graves, Elizabeth Atkins 53. Comorbidity in Pediatric OCD: Tourette Syndrom - Michael H. Bloch Section 7. Comorbidity 54. Mood and Anxiety Disorder Comorbidity in OCD - L. Baer, A. Fang, N.C. Berman, and W.E. Minichiello 55. Psychological Trauma Exposure and Obsessive-Compulsive symptoms - Dean McKay and Rachel Ojserkis 56. Eating Disorder Comorbidity with OCD - Marina Gershkovich, Olivia Pasucci, and Joanna Steinglass 57. Obsessive-Compulsive Symptoms in Schizophrenia: Clinical features, neurobiological correlates and treatment - Michael Poyurovsky 58. Differentiating Autism Spectrum disorder and OCD - Robert E. Accordino, W. Philip Bartel, Isobel W. Green, Christen L. Kidd, and Christopher J. McDougle 59. Personality Pathology in OCD: Comorbidity and Contrast with OCPD and Other Personality Disorders - Michael G. Wheaton and Anthony Pinto Section 8: Special Topics 60. Etiological models of OCD: anxiety, obsession, compulsion, completeness - Christopher Pittenger, Patricia Gruner, Thomas A. Adams, Benjamin Kelmendi 61. Evolutionary Perspectives of OCD - Gerrit I. van Schalkwyk and James F. Leckman 62. Research Domain Criteria and OCD: An oxymoron? - Eyal Kalanthroff, Gideon E. Anholt, and Helen Blair Simpson 63. OCD in Ethnoracial Minorities: Symptoms, barriers to care, and cultural considerations for treatment - Monnica T. Williams and Terence Ching 64. OCD in the Educational Setting - Allen H. Weg 65. The integration of new technological approaches in OCD care - Seth Feuerstein 66. OCD, Advocacy, and Addressing Stigma - Jeff Szymanski, Carly Bourne 67. Living with OCD - Elizabeth McIngvale