This is an introductory text for biochemistry courses, covering the grandeur of the fabric of biochemistry in sufficient detail and rigour for future chemists, biochemists and medical practitioners. Four themes unify this presentation of biochemistry; firstly, biochemistry is a body of knowledge compiled by people through experimentation; secondly, the unity of life and its variation through evolution; thirdly, that biological processes are organized into elaborate and interdependent control networks; and finally, biochemistry has important medical consequences.