Part I. Chapter. 1 HSCT: Historical perspectiveStorb, RChapter. 2 The EBMT: History, present & futureApperley, J; Gratwohl, A; Mohty, MChapter. 3 The donor registries (organization, regulation, international search...) Madrigal, A; Evseeva, IrinaChapter. 4 The HSCT Unit (minimal requirements, data manager trasplant coordinator) Aljurf, M; Niederwieser, Dietger; Rasheed, WalidChapter. 5 JACIE accreditation of HSCT programs Saccardi, RChapter. 6Statistics in HSCT and Cellular Therapies Labopin, M; Iacobelli, S; de Wreede, Liesbeth; Szydlo, Richard
Part II. Chapter. 7 Biological properties of HSC: scientific basis for HSCT Chabannon, C ; Aiuti, MChapter. 8 Biological properties of cells other than HSC (adaptative, abT, Treg, DC. Innete gdT, IELs MSC, NK) Toubert, A; Koehl, U; Bondanza, AChapter. 9 Histocompatibility (main concepts on HLA) K. Fleischhauer; SpieringsChapter. 10 Clinical & biological concepts for mastering Immune reconstitution after HSCTBoelens, J; Kuball, J
Part III. Chapter. 11 Evaluation and counselling of candidates Rambaldi, AChapter. 12 Donor selection for adults and pediatrics Ayuk, F; Balduzzi, AChapter. 13 Conditioning (MAC, RIC, NMA; including TBI) Nagler, AChapter. 14 Bone marrow harvest Gorin, ClaudeChapter. 15 Mobilization and collection of HSC Hubel, KChapter. 16 Collection of HSC in childrenPeters, C; Witt, VolkerChapter. 17 Processing, cryopreserving, and controlling the quality of HSC Wuchter, PatrickChapter. 18 Procurement and management of cord bloodRocha, V; Querol, SChapter. 19 Graft manipulation Handgretinger, RChapter. 20 Documentation of engraftment and chimerism after HSCT Bader, PChapter. 21 Short and long term controls after HSCT Shimoni, A
Part IV. Chapter. 22 Vascular access Cesaro, SChapter. 23 Transfusion supportSchrezenmeier, HChapter. 24 Fluid and electrolyte managementMasszi, T; Baumgartner, AnnicChapter. 25 GVHD prophylaxis (immunosuppression) Socie, GChapter. 26 Management ATG (SIRS) F. BonifaziChapter. 27 Infections control and isolation procedures Mikulska, M Chapter. 28 Pain management Ahmedzai, SHChapter. 29 Specific aspects of management in childrenCastagnola, Elio; Riccardi, FChapter. 30 Vaccinations de la Camara, RafaChapter. 31 Psychological support Moreno, E ; Schulz-Kindermann, F ; Polomeni, AliceChapter. 32 Relevant pharmacological interaction Bauters, TChapter. 33 Role of nursing in HSCT Babic, A; Murray, JChapter. 34 Ethical issues in HSCT Dalle, JH; El-Ghariani, K
Part V. Chapter. 35 Quality assessment of life after HSCT for pediatric and adults Barata, Anna; Jim, HeatherChapter. 36 Neutropenic fever Mikulska, M Chapter. 37 Bacterial infections Averbuch, DChapter. 38 Invasive fungal infections Maertens, JChapter. 39 Viral infections (CMC, EVB, VZV, HSV, HHV6, Resp. V, HCV, HBV...) & anti-viral cell therapyLjungman, P; Styczynski, J; Einsele, HermannChapter. 40 Other infections in HSCT (Tuberc, Toxo, PCJ, Noc, List.) Martino, RChapter. 41 Bleeding and thrombotic complicationsSavani, BChapter. 42 Graft failureValcarcel , D; Sureda, AChapter. 43 Early complications of endothelial origin Carreras, EChapter. 44 Acute GvHD Greinix, H; Holler, E; Zeiser, RChapter. 45 Chronic GvHD Wolff, D; Lawitschka, AChapter. 46 Post-transplant lymphoproliferative syndromesStyczynski, J ; Giebel, SChapter. 47 Iron overloadAngelucci, EChapter. 48 Secondary neoplasia (other than PTLPS) Tichelli, A
Part VI. Chapter. 49 Specific organ complications: Ocular / oral / pulmonary / hepatic Ruutu, T; Hashmi, SChapter. 50 Gastrointestinal complicationsBasak, GChapter. 51 Hemorrhagic cystitis and renal dysfunctionCesaro, SChapter. 52 Pulmonary complications Carreras, EChapter. 53 Neurological complications Dulery, RChapter. 54 Specific organ complications: Skin, hair, musculoskeletal Ayuk, F; Savani, BChapter. 55 Cardiovascular diseases and metabolic syndrome Snowden, J; Greenfield, DChapter. 56 Endocrine, fertility and sexual healthSalooja, N; Shoham, Z; Balduzzi, A
Part VII. Chapter. 57 Monitoring MRD in ALL Bader, P; Ossenkoppele, GChapter. 58 Preventing/treating relapse with drugsKroeger, N; Mohty, MChapter. 59 Preventing relapse by mean cells (DLI, aBT, subsets, tumour specific T cells) Kuball, J; Falkenburg, JH Fred; Kolb, HJ; Locatelli, FChapter. 60 Cellular therapy (CAR T, TCR T, suicide genes) with management and side effectsBonini, C; Hudecek, Michael; Fehse, Boris; Bondanza, AChapter. 61 Mechanisms of Immune resistance and overcoming immune resistance (checkpoint...)Dazzi, F; Vago, LChapter. 62 Regulatory Aspects of ATMP versus minimally manipulated immune cellsMc Grath, E; Chabannon, C
Part VIII. Chapter. 63 At-home HSCT Fernandez-Aviles, FChapter. 64 Cord blood HSCT (adults & children) Veys, P; Rocha, V; Sanz, JChapter. 65 Haploidentical HSCT (TCD and TC-repleted)Ciceri, F ; Bacigalupo, AChapter. 66 Photopheresis in adults and pediatrics Greinix, H; Gennery, AChapter. 67 Pediatric aspects of haploidentical HSCT Gennery, A; Bertaina, A; Slatter, M; Lankester, A; Albert, MChapter. 68 Overweight and obese patients Langebrake, C Chapter. 69 HSCT in Elderly patiens Duarte, R
Part IX. Chapter. 70 EBMT indication for allo and auto HSCT BOARDChapter. 71 AML in adults (incl APL) Nagler, A; Cornelissen, J; Craddock, C; Sanz, MAChapter. 72 AML in children Gibson, B ; Sauer, MChapter. 73 ALL in adults Marks, D ; Stelljes, MChapter. 74 ALL in children and adolescents Peters, C; Locatelli, F; Bader, PChapter. 75 Myelodysplastic syndromes de Witte, T; Robin, MChapter. 76 Refractory Anemia and JMML in children Niemeyer, CMChapter. 77 Myelodysplastic/myeloproliferative syndromes Onida, F; Chalandon, Y Chapter. 78 Myeloproliferative neoplasms (CML, PM, other MPN) Olavarria E; Kroeger, NChapter. 79 Severe aplastic anemia and PNHDufour C; Peffault de la Tour, R; Risitano, Antonio MariaChapter. 80 Fanconi anemia and other hereditary BMF syndromesFioredda, F; Strahm, B; Diaz de Heredia, Cristina; Dalle, JH; Bierings, MarcChapter. 81 Hemoglobinopathies (SCA)Gluckman, E; Abboud, MiguelChapter. 82 Multiple myeloma Mohty, M; Blade, Joan; Bruno, BChapter. 83 Systemic light chain amyloidosis Schoenland, S; Minnema, MChapter. 84 POEMS syndrome and disease produced by other monoclonal Igs Cook, G; Rovira, MChapter. 85 Low grade NHL (follicular, MALT, MW) Robinson, S; Kyriacou, CChapter. 86 Chronic lymphoid leukemia Dreger, P; Schetelig, JohannesChapter. 87 Diffuse large B cell NHL Bazarbachi, A; Schmitz, NChapter. 88 Mantle cell lymphoma Dietrich, S; Hermine, OChapter. 89 Other T- and B-aggressive lymphomas (Burkitt, LL, PTCL) & Lymphomas associated to HIVHubel, K; Montoto, SChapter. 90 Hodgkin lymphoma Sureda, A; Martinez, CarmenChapter. 91 Primary immunodeficiency diseasesLankester, A; Gennery, A; Albert, MChapter. 92 Inborn error of metabolism and osteopetrosis Schulz, A; Wynn, RChapter.93 Autoimmune disease Snowden, J; Rovira, M; Alexander, T ; Sharrack, B ; Farge, DChapter.94 Solid tumors (adults and children)Lanza, F; Ladenstein, R
AppendixEBMT Registry Ruiz, C; Hewer