1. Vitamin D: Historical OverviewHector F. DeLuca2. Genomic Determinants of Vitamin D Regulated Gene Expression J. Wesley Pike, Mark B. Meyer, Nancy A. Benkusky, Seong Min Lee, Hillary St. John, Alex Carlson, Melda Onal and Sohel Shamsuzzaman 3. Inhibitors for the Vitamin D Receptor-Coregulator InteractionKelly A. Teske, Olivia Yu and Leggy A. Arnold4. Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties Anna Y. Belorusova and Natacha Rochel5. Crystal Structure of the Vitamin D Receptor Ligand-binding Domain with Lithocholic AcidsTeikichi Ikura and Nobutoshi Ito6. 25-Hydroxyvitamin D-24-Hydroxylase (CYP24A1): a Key Regulator of 1,25(OH)2D3 Catabolism and Calcium HomeostasisVaishali Veldurthy, Ran Wei, Megan Campbell, Kamil Lupicki, Puneet Dhawan and Sylvia Christakos 7. Analogs of 1a,25-Dihydroxyvitamin D3 in Clinical UseHector F. DeLuca and Lori A. Plum8. 1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of AgeMark R. Haussler, G. Kerr Whitfield, Carol A. Haussler, Marya S. Sabir, Zainab Khan, Ruby Sandoval and Peter W. Jurutka9. Hedgehog and Vitamin D Signaling Pathways in Development and DiseaseM. Kyle Hadden10. Molecular Approaches for Optimizing Vitamin D SupplementationCarsten Carlberg11. The Role of Vitamin D3 in the Development and Neuroprotection of Midbrain Dopamine NeuronsRowan P. Orme, Charlotte Middleditch, Lauren Waite and Rosemary A. Fricker12. Vitamin D and Cardiac DifferentiationIrene M. Kim, Keith C. Norris and Jorge N. Artaza13. Vitamin D in Prostate CancerJungmi Ahn, Sulgi Park, Baltazar Zuniga, Alakesh Bera, Chung Seog Song and Bandana Chatterjee14. Metabolism and Action of 25-Hydroxy-19-nor-Vitamin D3 in Human Prostate CellsEiji Munetsuna, Atsushi Kittaka, Tai C Chen and Toshiyuki Sakaki15. Vitamin D Analogs with Nitrogen Atom at C2 Substitution and Effect on Bone FormationAtsushi Kittaka, Masashi Takano and Hiroshi Saitoh16. Mechanistic Insights of Vitamin D Anti-Cancer EffectsYingyu Ma, Candace S. Johnson and Donald L. Trump17. Vitamin D Signaling Modulators in Cancer TherapyWei Luo, Candace S. Johnson and Donald L. Trump