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Brain Norepinephrine Gregory A. Ordway (University of Mississippi)

Brain Norepinephrine By Gregory A. Ordway (University of Mississippi)

Brain Norepinephrine by Gregory A. Ordway (University of Mississippi)

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Summary

Norepinephrine is a chemical neurotransmitter. Noradrenergic drugs have been proven effective for depression and ADHD, and drugs that directly manipulate central nervous system norepinephrine are being developed for new disease indications. This book synthesizes evidence, practice and research to highlight norepinephrine's contribution to disease and therapy.

Brain Norepinephrine Summary

Brain Norepinephrine: Neurobiology and Therapeutics by Gregory A. Ordway (University of Mississippi)

Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

About Gregory A. Ordway (University of Mississippi)

Dr Ordway is Chair of the Department of Pharmacology at the James H. Quillen College of Medicine at East Tennessee State University. Dr Schwartz is Clinical Professor of Psychiatry at the University of Hawaii. He is also Adjunct Professor of Philosophy and Adjunct Professor of Psychiatry at the University of Louisville in Louisville, Kentucky, and serves as Medical Director of the Irwin Foundation in Austin, Texas. Dr Alan Frazer is Chair of the Department of Pharmacology at The University of Texas Health Science Center at San Antonio. He is also a Professor in the Department of Psychiatry at UTHSCSA and is an adjunct Professor in pharmacology departments at the College of Pharmacy of the University of Texas in Austin, and the School of Medicine of the University of Pennsylvania.

Table of Contents

Introduction: revision of an old transmitter Gregory A. Ordway; Part I. The Neurobiology of Norepinephrine: 1. Neuroanatomical and chemical organization of the locus coeruleus Kimberly L. Simpson and Rick C. S. Lin; 2. Interactions of norepinephrine with other neurotransmitter systems: anatomical basis and pharmacology Craig A. Stockmeier and Gregory A. Ordway; 3. Receptors for norepinephrine and signal transduction pathways David B. Bylund; 4. Regulation of gene transcription in the central nervous system by norepinephrine Ronald S. Duman and Samuel S. Newton; 5. The norepinephrine transporter and regulation of synaptic transmission Subbu Apparsundaram; Part II. Norepinephrine and Behavior: 6. Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep wake cycle Gary S. Aston-Jones, Monica Gonzalez and Scott Doran; 7. Locus coeruleus and regulation of behavioral flexibility and attention: clinical implications Gary S. Aston-Jones, Michiyo Iba, Edwin Clayton, Janusz Rajkowski and Jonathan Cohen; 8. Norepinephrine and long-term memory function Benno Roozendaal; 9. Norepinephrine and stress David A. Morilak; Part III. The Biology of Norepinephrine in CNS Pathology: 10. Animal models of psychopathology: focus on norepinephrine Leonie A. M. Welberg and Paul Plotsky; 11. Neuropathology of central norepinephrine in psychiatric disorders: postmortem research Gregory A. Ordway; 12. Norepinephrine in mood disorders Pedro L. Delgado and Cristinel Coconcea; 13. Noradrenergic pathology and pain Antti Pertovaara; 14. Norepinephrine in cognitive disorders Amy F. T. Arnsten; 15. Norepinephrine in neurological disorders Francesco Fornai; 16. Genetics of noradrenergic neurobiology Inna Belfer and David Goldman; Part IV. Psychopharmacology of Norepinephrine: 17. Actions of antidepressant and other drugs on norepinephrine systems Elliott Richelson; 18. The clinical role of norepinephrine antidepressants in depression and anxiety disorders J. Craig Nelson; 19. Norepinephrine in attention deficit hyperactivity disorder Fred W. Riemherr, Michael A. Schwartz, B. K. Marchant and E. Higgins; 20. Psychopharmacology of norepinephrine in eating disorders Katherine A. Halmi and Sun Young Yum; 21. Role of norepinephrine in substance abuse Susan L. Broom and Bryan K. Yamamoto.

Additional information

NPB9780521834919
9780521834919
0521834910
Brain Norepinephrine: Neurobiology and Therapeutics by Gregory A. Ordway (University of Mississippi)
Gregory A. Ordway (University of Mississippi)
New
Hardback
Cambridge University Press
2007-02-15
662
N/A
Book picture is for illustrative purposes only, actual binding, cover or edition may vary.
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