J.A. Miller and Y.-J. Surh, Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds. Glutathione-Dependent Toxicity: C. Andersson, E. Mosialou, R. Weinander, and R. Morgenstern, Enzymology of Microsomal Glutathione S-Transferase. B. Ketterer and L.G. Christodoulides, Enzymology of Cytosolic Glutathione S-Transferases. A.J.L. Cooper, Enzymology of Cysteine S-Conjugate b-Lyases. W. Dekant, S. Vamvakas,and M.W. Anders, Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate b-Lyase Pathway. T.A. Baille and K. Kassahun, Reversibility in Glutathione-Conjugate Formation. T.J. Monks and S.S. Lau, Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites. F.P. Guengerich, Metabolism and Genotoxicity of Dihaloalkanes. R. Munday, Bioactivation of Thiols by One-Electron Oxidation. N. Ballatori, Glutathione Mercaptides as Transport Forms of Metals. Sulfate Conjugate-Dependent Toxicity: C.N. Falany and T.W. Wilborn, Biochemistry of Cytosolic Sulfotransferases Involved in Bioactivation. C.J. Michejda and M.B.K. Koepke, Carcinogen Activation by Sulfate Conjugate Formation. Glucuronide Conjugate-Dependent Toxicity: K.W. Bock UDP-Glucuronsyltransferases and Their Role in Metabolism and Disposition of Carcinogens. P. Zia-Amirhosseini, H. Spahn-Langguth, and L.Z. Benet, Bioactivation of Glucuronide-Conjugate Formation. Bioactivation and Bioconversion: P.E. Hanna, N-Acetyltransferases, O-Acetyltransferases, and N,O-Acetyltransferases: Enzymology and Bioactivation. M.W. Anders and W. Dekant, Aminoacylases. J.L. Hoffman, Bioactivation by S-Adenosylation, S-Methylation, or N-Methylation. S. Vamvakas and M.W. Anders, Bioconversion of Prodrugs by Conjugate-Processing Enzymes. Subject Index.