Part I - High Intensity Focused Ultrasound Ablation of Pathological Tissue.- Chapter 1. HIFU Tissue Ablation: Concept & Devices G. Ter Haar.- Chapter 2. Prostate Focused Ultrasound Therapy J.Y. Chapelon, O. Rouviere, S. Crouzet, A. Gelet.- Chapter 3. MRI-guided HIFU Methods for the Ablation of Liver and Renal Cancers B.D. de Senneville, C. Moonen, M. Ries.- Chapter 4. Magnetic Resonance-guided High Intensity Focused Ultrasound Ablation of Breast Cancer.- F.M. Knuttel, M.A.A.J. van den Bosch.- Chapter 5. HIFU for Palliative Treatment of Pancreatic Cancer.- T.D. Khokhlova, J.H. Hwang.- Chapter 6. MR-guided Transcranial Focused Ultrasound.- J.F. Aubry, M. Tanter.- Chapter 7. Focused Ultrasound & Lithotripsy.- T. Ikeda, S. Yoshizawa, N. Koizumi, M. Mitsuishi, Y. Matsumoto.- Chapter 8. Heat-based Tumor Ablation: Role of the Immune Response F. Wu.- Part II - Drug and Gene Delivery using Bubble-assisted Ultrasound.- Chapter 9. Droplets, Bubbles and Ultrasound Interactions O. Shpak, M. Verweij, N. de Jong, M. Versluis.- Chapter 10. Sonoporation: Concept and Mechanisms A. Bouakaz, A. Zeghimi, A.A. Doinikov.- Chapter 11. Design of Microbubbles for Gene/Drug Delivery T. Bettinger, F. Tranquart.- Chapter 12. Co-administration of Microbubbles and Drugs in Ultrasound-assisted Drug Delivery: Comparison with Drug-carrying Particles R. Suzuki, A.L. Klibanov.- Chapter 13. Drug-loaded Perfluorocarbon Nanodroplets for Ultrasound-mediated Drug delivery N. Rapoport.- Chapter 14. Bubble-assisted Ultrasound: Application in Immunotherapy and Vaccination J.M. Escoffre, R. Deckers, C. Bos, C. Moonen.- Chapter 15. Sonoporation: Application for Cancer Therapy.- J. Qin, T.Y. Wang, J.K. Willmann.- Chapter 16. Microbubble-assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System A. Burgess, K. Hynynen.- Chapter 17. Microbubbles & Ultrasoun: Therapeutic Applications in Diabetic Nephropathy W.J. Cao, P.N. Matkar, H.H. Chen, A. Mofid, H. Leong-Poi.- Chapter 18. Drug and Gene Delivery using Sonoporation for Cardiovascular Disease J. Castle, S.B. Feinstein.- Chapter 19. Sonothrombolysis K.B. Bader, G. Bouchoux, C.K. Holland.- Part III- Other Ultrasound Therapy.- Chapter 20. Ultrasound-mediated Polymeric Micelle Drug Delivery H. Xia, Y. Zhao, R. Tong.- Chapter 21. Stimulation of Bone Repair with Ultrasound.- F. Padilla, R. Puts, L. Vico, A. Guignadon, K. Raum.- Chapter 22. Sonodynamic Therapy: Concept, Mechanism & Application to Cancer Treatment A.P. McHale, J.F. Callan, N. Nomikou, C. Fowley, B. Callen