Part 1 General aspects of the headaches: historical background, Hansruedi Isler, F. Clifford Rose; classification of headache, Jes Olesen; epidemiology of headache, Birthe Krog Rasmussen, Richard B. Lipton; impact of headache on the individual sufferer, Glen D. Solomon, Carl G.H. Dahlof; socioeconomic costs of headache, Philippe Michel; clinical approach to the headache patient, Peter J. Goadsby, Ninan T. Mathew; clinical pharmacology and randomized controlled clinical trials in headache, Carl G.H. Dahlof, Peer Tfelt-Hansen; ethical issues in headache research and management, Timothy J. Steiner, Povl Riis. Part 2 Basic science aspects of the headaches: anatomy of muscles, tendons, joints, blood vessels, and meninges, Lars Edvinsson, Erik Dahl; anatomy of central nervous system pathways related to head pain, Karl Messlinger, Rami Burstein; cephalic neurovascular transmitters and receptors, Inger Jansen-Olesen, Lars edvinsson; peripheral activation and sensitization of nociceptors, Andrew M. Strassman et al; central transmission of cephalic pain, Jonathan O. Dostrovsky, Andrew M. Strassman; inhibition of nociception, Jurgen Sandkuhler, Troels Staehelin Jensen; central sensitization and headache, rami Burstein, Clifford J. Wood; serotonin receptors - relevance to migraine pathogenesis and treatment, edith Hamel; the trigeminal system, Margarita Sanchez del rio, Michael A. Moskowitz; classification and structure of ion channels, Olaf Pongs; physiology of ion channels, Frank Lehmann-Horn, Karin Jurkat-Rott; channelopathies and their possible relations to migraine, Dennis E. Bulman; regulation and function of intracellular calcium in neurons, vascular smooth muscle, and endothelium, Masamitsu Iino; cortical spreading depression, Martin Lauritzen; animal models of headache, Peter J. Goadsby, Holger Kaube; human models of headache, Lars Lykke Thomsen, Jes Olesen; measurement of experimental and clinical head pain, Jannick Brennum, Richard H. Gracely; psychological modulation of pain, Peter D. Drummond, Keneth A. Holroyd. Part 3 The migraines: the migraines - introduction, Jes Olesen; epidemiology of migraine, Birthe Krog Rasmussen, walter F. Stewart; migraine comorbidity, Kathleen Ries Merikangas, Birthe Krogh Rasmussen; genetics of migraine, Michel D. Ferrari, Michael Bjorn Russell; biochemistry of systemic and jugular venous blood, Michel D. Ferrari, Flemming W. Bach; influence of female hormones on migraine, Helene Massiou, Marie-Germaine Bousser; platelets and adaptive responses in migraine, Rajiv Joseph et al; immunologic aspects of migraine, Andre Pradalier. (Part contents).