Part I. Biology of Nitric Oxide. The Biological Chemistry of Nitric Oxide, Joseph Loscalzo. Cell and Molecular Biology of Nitric Oxide Synthases, Olivier Feron and Thomas Michel. Cellular Signal Transduction and Nitric Oxide, Stanley Heydrick. Regulation of Gene Expression by Nitric Oxide, Ami A. Deora and Harry M. Lander. Cytotoxicity, Apoptosis, and Nitric Oxide, Stefanie Dimmeler and Andreas M. Zeiher. Nitric Oxide and Ion Channels, Victoria M. Bolotina. Role of Nitric Oxide in Vasomotor Regulation, Richard A. Cohen. Nitric Oxide and Platelet-Mediated Hemostasis, Elisabeth M. Battinelli and Joseph Loscalzo. Nitric Oxide Modulates Leukocyte-Endothelial Cell Adhesion, Wolfgang Cerwinka and D. Neil Granger. Nitric Oxide and Cardiomyocyte Function, Jean-Luc Balligand and Paul J. Cannon. The Fibroblast and Nitric Oxide, Peter Brecher. Nitric Oxide in Cardiac Electrophysiology, Lu Fei and Douglas P. Zipes. Part II. Cardiovascular Pathophysiology of Nitric Oxide. Nitric Oxide and Endothelial Dysfunction, Gerard A. Dillon and Joseph A. Vita. Nitric Oxide and Hypertension, M. Audrey Rudd, Maria R. Trolliet, and Joseph Loscalzo. Nitric Oxide and Pulmonary Hypertension, John J. Leopore and Kenneth D. Bloch. Nitric Oxide in Atherosclerosis, Robert T. Eberhardt and Joseph Loscalzo. Thrombotic Disorders and Nitric Oxide Insufficiency, Jane E. Freedman and Joseph Loscalzo. Myocardial Nitric Oxide in Heart Failure, Douglas B. Sawyer and Wilson S. Colucci. Shock States and Nitric Oxide, Hartmut Ruetten and Christoph Thiemermann. Stroke and Nitric Oxide, Nancy E. Stagliano and Paul L. Huang. The Role of Nitric Oxide in Ischemia-Reperfusion, Allan M. Lefer and Reid Hayward. Part III. Nitric Oxide in Cardiovascular Therapeutics. Nitrovasodilators, John D. Horowitz. S-Nitrosothiols, Jane A. Leopold and Joseph Loscalzo. Diazeniumdiolates (Formerly NONOates) in Cardiovascular Research and Potential Clinical Applications, Joseph E. Saavedra, Anthony L. Fitzhugh, and Larry K. Keefer.Inhaled Nitric Oxide Therapy for Acute Respiratory Failure, William Hurford and Warren M. Zapol. Antioxidants and Endothelium-Derived Nitric Oxide Action, Annong Huang and John F. Keaney, Jr. Coating Arterial and Blood-Contacting Surfaces with NO*-Donating Compounds, John D. Folts and Joseph Loscalzo. Gene Therapy and Nitric Oxide, Heiko E. von der Leyen. Nitric Oxide and Tissue Preservation in Transplantation, David J. Pinsky and David M. Stern. L-Arginine: Its Role in Cardiovascular Therapy, Andrew J. Maxwell and John P. Cooke. Index.