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Estrogens and Memory Summary

Estrogens and Memory: Basic Research and Clinical Implications by Karyn M. Frick (Professor of Psychology, Professor of Psychology, University of Wisconsin-Milwaukee)

Estrogens are key modulators of brain regions that mediate learning and memory formation. This regulation has significant translational implications, as estrogens contribute to age-related memory decline and dementia, emotional disorders, addiction, and recovery from brain injury. Although the importance of estrogens for memory formation has been well accepted within the behavioral neuroendocrinology community, it has yet to be fully appreciated by neuroscientists outside of the discipline. Recent National Institutes of Health policies on the inclusion of sex as a biological variable in grant applications will force thousands of researchers to consider hormonal regulation of memory for the first time. However, the majority of these researchers are not trained endocrinologists, and no previous monograph comprehensively encompasses the breadth of basic and clinical research on this subject. Thus, this book provides a vital resource for non-endocrinologists and endocrinologists alike. Estrogens and Memory: Basic Research and Clinical Implications provides a compendium of cutting-edge basic and clinical research describing the ways in which estrogens regulate memory in a variety of species. Chapters are written by leading experts whose work is on the forefront of this exciting field. Three fundamental discussions focus on: effects of estrogens on the hippocampus and other brain regions central to memory, effects of estrogens on memory and related cognitive processes throughout the lifespan, and translational implications of estrogenic regulation of memory for aging and disease.

Estrogens and Memory Reviews

Estrogens and Memory: Basic Research and Clinical Implications provides a very important, current overview of a field that has opened up the brain as an important target of sex hormones that affect cognitive, emotional, and motor functions throughout the brain and not just reproduction. The book includes chapters by leading researchers on this topic and covers basic molecular and behavioral mechanistic studies as well as clinical findings. * Bruce S. McEwen, PhD, Alfred E. Mirsky Professor, Head of the Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University *
How do estrogens regulate memory? It depends. Estrogens and Memory: Basic Research and Clinical Implications introduces readers to important questions concerning the interaction of long-term and rapid mechanisms that regulate estrogenic effects on memory, neuroprotection, and maintenance of brain function in the face of stressors, brain damage, disease, and reduced responsiveness during aging. In addition to supporting the idea that estrogens are rapid neuromodulators of memory, the pros and cons for hormone therapy in women are highly debated, and differing opinions and putative reasons for conflicting results are clearly presented and discussed in depth. This book would form a solid foundation for a course on the effects of estrogens on the neurons underlying memory formation. * Thomas C. Foster, PhD, Professor in the Department of Neuroscience and Genetics and Genomics Program, and Evelyn F. McKnight Chair for Research on Cognitive Aging and Memory, University of Florida *
Understanding the role of estrogens in mediating memory is key to elucidating critical questions of human health such as: How are estrogens involved in the memory aspects of neuropsychiatric disorders? Are those memory circuits established before birth? What are the underlying causes of Alzheimer's disease in women? Can estrogens be used therapeutically to maintain memory function as we age? This outstanding compendium of research from scientists at the cutting edge of estrogen research provides the tools to think about all of these important questions and more. Organized to present a translational and trans-species perspective, it moves from the molecular to the behavioral as it presents a lucid and deep exposition of current knowledge that will inspire and underscore estrogens' key role in memory, one of the essential attributes that make us human. * Gillian Einstein, PhD, Professor of Psychology, University of Toronto, Wilfred and Joyce Posluns Chair in Women's Brain Health and Aging *

About Karyn M. Frick (Professor of Psychology, Professor of Psychology, University of Wisconsin-Milwaukee)

Dr. Frick is a behavioral neuroscientist and neuroendocrinologist. She is a Professor of Psychology at the University of Wisconsin-Milwaukee, and an Adjunct Professor of Pharmacology and Experimental Therapeutics at the Medical College of Wisconsin.

Table of Contents

Contributors Introduction Karyn M. Frick Part I Estrogen effects on the hippocampus and related brain regions 1. Estrogen receptor distribution in the hippocampus and prefrontal cortex Annelyn Torres-Reveron, Wayne G. Brake, and Teresa A. Milner 2. Estrogen receptors at the membrane: Interactions with metabotropic glutamate receptors and caveolin proteins regulated through palmitoylation Katherine R. Tonn, Paul G. Mermelstein, and John Meitzen 3. Rapid effects of estradiol on dendritic spines and synaptic plasticity in the male and female hippocampus Asami Kato, Gen Murakami, Yasushi Hojo, Sigeo Horie and Suguru Kawato 4. Rapid modulation of spinogenesis by estradiol in the neocortex: An emerging role for GPER? Deepak P. Srivastava, Katherine J. Sellers, Peter D. Evans 5. Estrogenic regulation of synaptic actin proteins and plasticity Enikoe A. Kramar 6. Hippocampal synaptic stability and plasticity: The role of hippocampus-derived estradiol Gabriele M. Rune 7. Estrogenic regulation of glia and neuroinflammation Andrea Crespo-Castrillo, Maria Angeles Arevalo, Luis M. Garcia-Segura, and Natalia Yanguas-Casas Part II Estrogenic regulation of memory and related cognitive processes throughout the lifespan 8. Molecular mechanisms underlying rapid effects of estradiol on memory consolidation Karyn M. Frick, Jaekyoon Kim, Wendy Koss, and Jennifer J. Tuscher 9. Estrogenic regulation of spatial memory in songbirds David J. Bailey and Colin J. Saldanha 10. Estrogenic regulation of recognition memory and spinogenesis Victoria N. Luine and Maya Frankfurt 11. Who are you and what do you know? Estrogenic regulation of social recognition and social learning Paul A.S. Shepard, Talya Kuun, Pietro Paletta, and Elena Choleris 12. Estrogens have their ups and downs: A multiple memory systems approach to the bidirectional effects of estrogens on learning strategy Donna L. Korol 13. Puberty: Effects on the prefrontal cortex and cognitive behavior Janice M. Juraska 14. Ovarian hormones, cognition, and reproductive aging: Applications and implications for translating preclinical endocrine brain research to the clinic Alesia A. Prakapenka, Veronica Pena, Heather A. Bimonte-Nelson 15. Estrogenic regulation of hippocampal neurogenesis throughout the lifespan Shunya Yagi, Rand Mahmoud, Wansu Qiu, Paula Duarte-Guterman, and Liisa A.M. Galea 16. Effects of estradiol on basal forebrain cholinergic neurons and their impact on cognitive performance and age-related cognitive decline Robert B. Gibbs 17. Estrogenic regulation of synaptic health and cognition in aging rhesus monkeys Johanna L. Crimins, Yuko Hara, John H. Morrison Part III Translational implications of estrogenic regulation of memory for aging and disease 18. Hormone therapy in postmenopausal women: The Women's Health Initiative Memory Study and its continuing impact on research and practice Ira Driscoll, Stephen R. Rapp, Karen C. Johnson, Mark A. Espeland 19. Estrogen treatment in Alzheimer's disease: Translational implications of estrogenic regulation of memory for aging and disease Kelly N. Morgan and Carey E. Gleason 20. Effects of dietary estrogens on dementia Shelina Kassam, Mira Soni, Eef Hogervorst 21. Oral contraceptive effects on cognition Soniya Assudani Patel, Courtney McQuade, Robert S. Astur 22. Effects of SERMS and antiestrogens on cognition in women with breast cancer Jeffrey D. Blaustein 23. Estrogen neuroprotection and anti-inflammation actions in the hippocampus Roshni D. Thakkar, Ruimin Wang, Gangadhara R. Sareddy, Ratna K. Vadlamundi, and Darrell W. Brann 24. Estrogenic regulation of neuroprotection and inflammation in ischemic stroke and aging Farida Sohrabji, Shameena Bake, Amutha Selvamani 25. Estradiol and fear generalization: Implications for anxiety disorders Aaron M. Jasnow, Jordan M. Adkins, and Joseph F. Lynch III 26. Role of estrogens in addiction-related learning Hanna Yousuf Part IV Conclusions and Future Directions 27. Moving forward: A vision for future research on estrogenic regulation of memory Karyn M. Frick Index

Additional information

NPB9780190645908
9780190645908
0190645903
Estrogens and Memory: Basic Research and Clinical Implications by Karyn M. Frick (Professor of Psychology, Professor of Psychology, University of Wisconsin-Milwaukee)
New
Hardback
Oxford University Press Inc
2020-02-20
528
N/A
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